Neurite formation of aging sensory ganglion cells

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In aging dorsal root ganglion (DRG) cell culture, DRG cells display the multipolar, bipolar or pseudounipolar forms. Some pseudounipolar neurons had many thin neurites elongated from the junction of the stem process or a structure-like swelling body or glomerulus (unipolar 2 cell type). These structures were not seen in fetal or newborn mouse DRG cell cultures. Unipolar2 neurons appeared with an incidence of about 5% in a medium without NTF or supplemented with NT-3, NT-4 or BDNF.However unipolar2 neurons increased about 30% in a medium supplemented with NGF.There is no difference of the number of surviving neurons in each of culture medium. The appearance of this type cell was affected by NGF, not affect other neurotrophic factors. It is suggested that adult DRG neurons remained only the low-affinity NGF-receptor(p75) but not the high-affinity NGF receptors(trk A, B, or C).