A new index for analysing ventriculo-arterial interactions : development of wave intensity

分析心室-动脉相互作用的新指标：波强度的发展

基本信息

批准号：
09680866
负责人：
NIKI Kiyomi
金额：
$ 1.79万
依托单位：
Tokyo Women's Medical University.
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Wave intensity is a new index for evaluating ventriculo-arterial interactions. Wave intensity is defined as (dP/dt)(dU/dt) at any site of the circulation, where dP/dt and dU/dt are the time derivatives of blood pressure and velocity, respectively. A positive value of wave intensity indicates that the effects of pressure waves traveling from the heart towards the periphery are predominant in the formation of pressure and velocity waveforms at the measuring site, while a negative value indicates that the effects of waves reflected from the periphery predominate. Arterial wave intensity in normal subjects have two positive sharp peaks. The first peak occurs during early systole when a forward-travelling compression wave is generated by the left ventricle. The magnitude of this peak increases markedly with the increase in cardiac contractility. The second peak, which occurs towards the end of systole, is caused by generation of a forward-travelling expansionwave.We obtained the carotid arterial wave intensity noninvasively. Using a combined Doppler and echo-tracking system, we simultaneously measured carotid arterial diameter and blood flow velocity. Since arterial pressure waveforms and diameter change waveforms are similar, we obtained a blood pressure waveform, noninvasively, by measuring the diameter and calibrating its peak and bottom values by systolic and diastolic blood pressure, measured with a cuff-type manometer. We examined characteristics of wave intensity in patients with various heart disease.The pattern of wave intensity varies considerably with the type heart disease. Wave intensity is useful for analysing ventriculo-arterial interaction in patients with heart disease.

波强度是评估心室 - 动脉相互作用的新指数。波强度定义为（DP/DT）（DU/DT）在循环的任何位点，DP/DT和DU/DT分别是血压和速度的时间衍生物。波强度的正值表明，从心脏向周围传播的压力波的影响主要在测量位点的压力和速度波形的形成中，而负值表示从外围反射的波的效应占主导地位。正常受试者中的动脉波强度具有两个正尖峰。当左心室产生前向旅行压缩波时，第一个峰发生在早期收缩期。随着心脏收缩率的增加，该峰的大小显着增加。第二个峰位于收缩期末端，是由前向旅行的膨胀波引起的。我们无创的颈动脉波强度获得了颈动脉波强度。使用组合的多普勒和回声跟踪系统，我们同时测量了颈动脉直径和血流速度。由于动脉压波形和直径变化波形相似，因此我们通过测量直径并通过收缩和舒张压来校准其峰值和底部值，通过收缩和舒张血压校准了血压波形，并通过袖口型测试表测量。我们检查了各种心脏病患者的波强度的特征。波强度的模式随心脏病型的差异很大。波强度可用于分析心脏病患者的心室相互作用。