Development and clinical application of the system for one-point measurement of pulse wave velocity

脉搏波速度单点测量系统的研制及临床应用

基本信息

批准号：
15500350
负责人：
NIKI Kiyomi
金额：
$ 2.24万
依托单位：
Tokyo Women's Medical University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500350/
关键词：
Ultrasonic measurements Arterial stiffness Pulse wave velocity (PWV)Cardiovascular disease Wave intensity Carotid artery Vascular age

项目摘要

The system is composed of a computer, a wave intensity (WI) unit and an Aloka ProSound SSD-6500 ultrasonic machine (Aloka, Tokyo) equipped with a combined tissue imaging (10 or 13 MHz) and Doppler (5 MHz) transducer. The WI unit receives RF echo signals and color Doppler signals from the ultrasonic machine, and calculates the change in diameter of the artery (M-mode echo tracking) and the mean blood velocity through the sampling gate (color M-mode Doppler). The system was completed in 2004. However, some problems in the software were found, and it took more than 1 year to fix them. We measured local pulse wave velocity (PWV) in the carotid artery in more than 150 normal subjects and patients with hypertension or other cardiovascular disease. We also measured Cardio Ankle Vascular Index (CAVI) with Vasera VS- 1000, which is one of the indices of mean arterial PWV obtained with a two-point measurement system, and compared the data with carotid arterial PWV obtained with our system. Carotid arterial PWV did not correlate with CAVI, which suggests that the progress in the arterial stiffness is not uniform and the analysis of local arterial stiffness with our system is useful for investigating the progress in regional arteriosclerosis.Our system can also obtain wave intensity indices at the same time. Wave intensity is a new index of the working condition of the heart interacting with arterial system. We studied the differences in the cold pressor response between patients with hypertension and normal subjects and reported the results at the congress in Europe (9^<th> Annual Meeting of the European Association of Echocardiography (Florence, 2005),

该系统由计算机，波强度（WI）单元和ALOKA PROSOUND SSD-6500超声机（Aloka，Tokyo）组成，配备了组合的组织成像（10或13 MHz）和多普勒（5 MHz）透射剂。 WI单元从超声机接收RF回声信号和颜色多普勒信号，并计算动脉直径的变化（M模式回声跟踪）和通过采样门（颜色M-Mode Doppler）的平均血速速度。该系统于2004年完成。但是，该软件中发现了一些问题，并花了1年以上的时间来修复它们。我们测量了150多名正常受试者和患有高血压或其他心血管疾病的患者的颈动脉中局部脉搏波速度（PWV）。我们还用Vasera VS-1000测量了有氧运动踝血管指数（CAVI），这是使用两点测量系统获得的平均动脉PWV指数之一，并将数据与我们系统获得的颈动脉动脉PWV进行了比较。颈动脉PWV与CAVI无关，这表明动脉刚度的进展并不统一，并且对我们系统的局部动脉僵硬度的分析对于研究区域动脉粥样硬化的进展很有用。波强度是与动脉系统相互作用的心脏工作条件的新指数。我们研究了高血压患者和正常受试者患者之间的冷压反应差异，并报告了欧洲国会的结果（9^<TH>欧洲超声心动图协会的年度会议（佛罗伦萨，2005年），2005年，