Mechanisms of blister formation in pemphigus foliacues analyzed by anti-Dsg1 monoclonal antibodies
Mechanisms of blister formation in pemphigus foliacues analyzed by anti-Dsg1 monoclonal antibodies
批准号:
15K09749
负责人:
ISHII Ken
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2015
资助国家:
日本
项目状态:
已结题
起止时间:
2015-04-01 至 2018-03-31
中文摘要
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英文摘要
期刊论文(7)
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p38MAPK contributes to loss of cell adhesion through clustering of desmoglein 1 but is not required for blistering in pemphigus foliaceus .
p38MAPK 通过桥粒芯糖蛋白 1 的聚集导致细胞粘附丧失,但对于落叶型天疱疮中的水泡来说并不是必需的。
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Yoshida K , Ishii K, Shimizu A , Yokouchi M , Amagai M ,John R.Stanley, Ishiko A]
通讯作者:
Ishiko A
Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris
脱发是从落叶型天疱疮到寻常型天疱疮的过渡病例
DOI:
10.1111/1346-8138.13957
发表时间:
2017
期刊:
The Journal of Dermatology
影响因子:
--
作者:
[Yoshida Kenji, Ishii Ken, Ishiko Akira]
通讯作者:
Ishiko Akira
Desmoglein 1 clustering in pemphigus foliaceus patients’ skin.
桥粒芯糖蛋白 1 聚集在落叶型天疱疮患者的皮肤中。
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Kenji Yoshida, Ken Ishii1, Mari Nakagawa, Akira Ishiko]
通讯作者:
Akira Ishiko
Polyclonal nature of pemphigus foliaceus IgG antibodies enhances pathogenic effect for blister formation in association with p38MAPK-dependent desmoglein 1 clustering.
落叶型天疱疮 IgG 抗体的多克隆性质增强了与 p38MAPK 依赖性桥粒芯糖蛋白 1 聚类相关的水疱形成的致病作用。
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Yoshida K, Ishii K , Shimizu A , Yokouchi M , Amagai M ,John R.Stanley , Ishiko A]
通讯作者:
Ishiko A
p38 MAPK signaling is necessary for desmoglein 1 clustering and enhances pathogenic effect, but is not required for blistering in pemphigus foliaceus
p38 MAPK 信号传导对于桥粒芯糖蛋白 1 聚类是必需的,并增强致病作用,但对于落叶型天疱疮中的水疱来说不是必需的
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[Yoshida K, Ishii K, Shimizu A, Yokouchi M, Amagai M, Stanley JR, Ishiko A]
通讯作者:
Ishiko A
共 6 条
Analysis of blister formation mechanism in pemphigus by a novel in vitro bead aggregation assay
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批准号:18K08278
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2018
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负责人:ISHII Ken
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依托单位:
detailed characterization of autoantibodies in paraneoplastic pemphigus by phage display
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批准号:23591628
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:ISHII Ken
-
依托单位:
Intra-and inter-cellular vaccine-induced signaling pathways
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批准号:21390152
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
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财政年份:2010
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负责人:ISHII Ken
-
依托单位:
Development of new objective methods to assess disease activity in pemphigus using monoclonal single-chain- variable-fragment antibodies
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批准号:20591328
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2008
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负责人:ISHII Ken
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依托单位:
In vivo molecular imaging for nerve injury
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批准号:19500328
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2007
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负责人:ISHII Ken
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依托单位:
Mechanism of nucleic ac id-based vaccine immunogenicity
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批准号:19390139
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2007
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负责人:ISHII Ken
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依托单位:
海外基金