Analysis of the interaction between the folate receptor beta expression macrophages and cancer stem cells in pancreatic cancer invasion

叶酸受体β表达巨噬细胞与肿瘤干细胞在胰腺癌侵袭中的相互作用分析

• 批准号: 25293288
• 负责人: TAKAO SONSHIN
• 金额: $ 11.56万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293288/
• 关键词: pancreatic cancer; cancer stem cell; CD133; macrophage; FRb-receptor; tumor microenvironment; miR-30; FRbeta; microRNA; invasion; migration; FRb receptor; fibrotic stroma; nude mouse; EMT; N-cadherin; miRNA; caerulein誘導慢性膵炎; FRβマクロファージ /

项目成果

The influence of miR-30 family to migration of a pancreatic cancer cell line, Capan-1

miR-30家族对胰腺癌细胞系Capan-1迁移的影响

• 发表时间: 2015
• 作者: Tsukasa K;Miyazaki Y;Ueno S;Obara T;Matsubara S;Yoshimitsu M;Matsuyama T,Takao S
• 通讯作者: Matsuyama T,Takao S

The role of miR-30a in the highly migratory pancreatic cancer cell line

miR-30a在高度迁移的胰腺癌​​细胞系中的作用

• 发表时间: 2014
• 作者: Tsukasa K;Matsubara S;Miyazaki Y;Obara T;Ueno S;Takao S
• 通讯作者: Takao S

The mTOR pathway as a mechanism to maintain pancreatic cancer stem cell properties and a target to eliminate stem-like cells

mTOR 通路作为维持胰腺癌干细胞特性的机制和消除干细胞样细胞的靶标

• 作者: Shyuichiro Matsubara;Qiang Ding;Yumi Miyazaki;Taisaku Kuwahata;Koichiro Tsukasa and Sonshin Takao
• 通讯作者: Koichiro Tsukasa and Sonshin Takao

Macrophage uptake and accumulation of folates are polarization‐dependent in vitro and in vivo and are regulated by activin A

• DOI: 10.1189/jlb.0613345
• 发表时间: 2014-05
• 期刊: Journal of Leukocyte Biology
• 影响因子: 5.5
• 作者: R. Samaniego;Blanca Soler Palacios;Ángeles Domiguez-Soto;C. Vidal;A. Salas;T. Matsuyama;C. Sánchez-Torres;Inmaculada Torre;M. Miranda-Carús;P. Sánchez-Mateos;A. Puig‐Kröger

CD133/ERK axis mediates invasion and metastasis through epithelial-to-mesenchymal transition (EMT) in pancreatic cancer

CD133/ERK轴通过上皮间质转化（EMT）介导胰腺癌的侵袭和转移

• 作者: Qiang Ding;Makoto Yoshimitsu;Koichiro Tsukasa;Yumi Miyazaki;Shoko Ueno;Ryoko Imakiire;Toru Obara and Sonshin Takao
• 通讯作者: Toru Obara and Sonshin Takao