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EPIDEMIOLOGICAL STUDY ON EFFECTS OF ENVIRONMENTAL AND BEHAVIORAL FACTORS ON CARDIOVASCULAR DISEASES AND ON DISEASE TREND PREDICTION

环境和行为因素对心血管疾病影响的流行病学研究及疾病趋势预测

基本信息

批准号：
59440036
负责人：
KOMACHI Yoshio
金额：
$ 7.36万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1985
项目状态：
已结题

项目摘要

Complete surveys were conducted in Akita and Osaka follow-up populations in 1960's, 1970's and 1980's to elucidate age-sex morbidity trends in stroke and coronary heart disease(CHD) and their risk characteristics, and changes in dietary habits with the acculturation to western living and eating patterns due to socio-economic developments. It was shown that effects of environmental and behavioral factors on the occurrence of cardiovascular diseases were clearly different between the older age groups(50y.o. and over) who had not been in the acculturation until the middle age, and the younger age groups(30-49) who had been from the young adult ages.(1)There were a significant decline in mean values of blood pressures and remarkable increase in mean serum total cholesterol(TC) at every age decade between 30 and 69 in both sexes in the Akita rural population. However, TC levels are still lower in the population than in Osaka urban populations. A decline in stroke, especially cerebral hemorrhage(CH) was seen at all age-sex groups. Multiple logistic analysis showed that contributions to CH risk became small for hypertension as a positive risk factor and for TC as a negative one. The positive correlation between hypertension and body mass index (BMI) become significant for men aged 30-39 and 40-49 in 1970's and 1980's whereas it was not in 1960's. Therefore, trends in the prevalence of hypertension associated with obesity should be carefully observed in the younger age groups.(2)In urban populations, blood pressure level were lower, and mean TC and BMI were higher during the past two decades compared with the rural population. There were decreasing trends in stroke incidence and increasing trends in coronary heart disease for men aged 40-59 in clerical and manual wokers so that the incidence rate of CHD became higher than that of stroke.

在1960、1970和1980年代对秋田和大阪随访人群进行了全面调查，以阐明卒中和冠心病（CHD）的年龄-性别发病率趋势及其风险特征，以及由于社会经济发展而适应西方生活和饮食模式的饮食习惯的变化。结果表明，环境因素和行为因素对心血管疾病发生的影响在年龄较大的人群（50岁~ 50岁）之间存在明显差异。中年后才开始文化适应的人，年龄更小的群体（30-49岁）从青年时期就开始了文化适应。(1)在30 ~ 69岁年龄段，秋田农村人口的平均血压显著下降，平均血清总胆固醇（TC）显著升高。然而，人口中的TC水平仍然低于大阪城市人口。中风，尤其是脑出血（CH）在所有年龄-性别群体中都有所下降。多元logistic分析显示，高血压作为正危险因素，而TC作为负危险因素，对CH风险的贡献较小。在20世纪70年代和80年代，30-39岁和40-49岁的男性中，高血压和体重指数（BMI）之间的正相关性变得显著，而在60年代则没有。因此，应仔细观察年轻人群中与肥胖相关的高血压流行趋势。(2)与农村人口相比，城市人口近20年血压水平较低，平均TC和BMI较高。40-59岁男性文职和体力劳动者卒中发病率呈下降趋势，冠心病发病率呈上升趋势，冠心病发病率高于卒中。