Integrative studies on the thermosensitivity of living body and the onset of thermoregulatory responses.

生物体热敏感性和体温调节反应发生的综合研究。

• 批准号: 59440026
• 负责人: NAKAYAMA TERUO
• 金额: $ 19.2万
• 依托单位: Osaka University Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1984
• 资助国家: 日本
• 起止时间: 1984 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-59440026/
• 关键词: Thermoregulation; Hypothalamus; Thermosensitive neuron; Brown adipose tissue; Respiratory gases; Saliva secretion; Intracranial self-stimulation; 運動; 視床; 脳波; 温度刺激; 侵害刺激; 唾液分泌; 炭酸ガス

1. Studies on thermosensitive neurons. (1) Activities of supraoptic and para-ventricular neurosecretory cells were facilitated by preoptic warming. (2) Scrotal warming in rats produced not only thermoregulatory responses but also non-specific responses such as EEG desynchronization. (3) Warm-sensitive neurons showing on-off type response at higher brain temperature were found in the posterior hypothalamus. (4) <CO_2> stimulated thermosensitive neurons in vivo, but depressed in vitro.2. Studies on thermoregulatory effectors. (1) Temperature signals generated in the preoptic area were transmitted to the hypothalamic ventromedial nucleus, which controlled brown adipose tissue thermogenesis. (2) Saliva secretion in anesthetized rats were observed at various experimental conditions. Central and peripheral temperature signals were integrated to produce salivation. Preoptic warming produced saliva secretion and body extension, while warming of the posterior hypothalamus caused grooming. (3) Intracranial self-stimulation with loaded bar press was observed at various internal and external thermal stresses. (4) Rectal temperature of rats running on a treadmill increased in proportion to the exercise intensity.

1.温敏神经元的研究。(1)视前加温促进视上和室旁神经分泌细胞的活动。(2)大鼠阴囊温热不仅产生体温调节反应，还产生非特异性反应，如EEG去极化。(3)在下丘脑后部发现了在较高脑温下呈开关型反应的温敏神经元。(4)在体内对温敏神经元有刺激作用，而在体外对温敏神经元有抑制作用.<CO_2>体温调节效应物的研究。(1)视前区产生的温度信号被传递到下丘脑腹内侧核，控制棕色脂肪组织产热。(2)在不同的实验条件下观察麻醉大鼠的唾液分泌。中央和外周温度信号被整合以产生流涎。视前区的升温产生唾液分泌和身体伸展，而下丘脑后部的升温引起梳理。(3)在不同的内部和外部热应力下，观察了颅内自刺激与加载杆压。(4)在跑步机上跑步的大鼠直肠温度与运动强度成比例增加。

项目成果

Matsumura, K. et al.: "Effects of carbon dioxide on preoptic thermosensitive neurons in vitro." Pflugers Arch. in press.

Matsumura, K. 等人：“二氧化碳对体外视前热敏神经元的影响。”

Jpn J Physiol. 35:375. (1985)

日本生理学杂志。

Tanaka,H.et al.: Physiology & Behavior. 38. 145-151 (1986)

Tanaka,H.et al.：生理学

Tamaki, Y. et al.: "Effects of air constituents on thermosensitivities of preoptic neurons: hypoxia versus hypercapnia" Pflugers Arch. in press.

Tamaki, Y. 等人：“空气成分对视前神经元热敏感性的影响：缺氧与高碳酸血症”Pflugers Arch。

Brain Research. 328-207. (1985)

大脑研究。