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Studies on Macrobial Metabolites Effective to Eucaryotic Cells

对真核细胞有效的微生物代谢产物的研究

基本信息

批准号：
60303026
负责人：
IWASAKI Shigeo
金额：
$ 4.1万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

项目摘要

YAMAZAKI isolated monoamine oxidase oxidase inhibitors, EA-1, TA-1, TL-1 and norsolorinic acid, as the metaboltes Emericella navahoensis and Talaromyces lutens, and their specific sctivity was clarified. OMURA searched for pletelet aggregation inhibitors form the metaboltes of Actinomycetes, and found such activity in several quinone antibiotics such as medermycin and nanaomycin. A new isotetracenoid, OM-4842, was slso identified. SUZUKI determined the total structure of N-acetylsporaviridin and the partial atructure of aculeximycin. MIKAMI prepared a vriety of derivatives of saframycin, an antitumor antibiotic, and structure-activity relationship was studied. YAMAMOTO searched for anti-L5178Y cell compounds, and isolated monorden from Macrophoma castaneicola, tyrosol from Glomellera cingulate and norbotryal etc from Botrytis cinerea. NAKAMURA determined the structures of neo-enactins, antifungal antibiotics. Their activities were evaluated. YAMAGUCHI searched for antifungal antibiotics by a screening system using a wild type and a mutant strains of Candida albicans and isolated a compound. NATORI studied on the metabolites of Phomopsis sp., and isolated a varietyof cytochalasan compounds. SATO found that diethylstibestrol (DES) effects on myclotubule assembly. The action of DES and related compounds were studied. NOZOE studied on the metabolitesd of Basidiomycete, and isolated several antibiotics. FUJITA studied on the peptidic containing -amino-isobutylic acid as their components, and their structures were established. OKUDA and IWASAKI isolated several anti-mitotic compounds and their mode of action was studied. A screening system using Pyricularia oryzae was also deviced.

YAMAZAKI分离出单胺氧化酶氧化酶抑制剂EA-1、TA-1、TL-1和去盐酸，作为纳瓦霍青Emericella navahoensis和Talaromyces lutens的代谢物，并明确了它们的特异性活性。OMURA在放线菌代谢产物中寻找pletellet聚集抑制剂，并在几种醌类抗生素如甲德霉素和纳霉素中发现了这种活性。一个新的类异四烯化合物OM-4842也被鉴定出来。SUZUKI测定了n -乙酰sporaviridin的总结构和阿霉素的部分结构。MIKAMI制备了多种抗肿瘤抗生素saframycin衍生物，并对其构效关系进行了研究。YAMAMOTO寻找抗l5178y细胞化合物，从castaneicola巨噬细胞中分离到monorden，从Glomellera cingulate中分离到tyrosol，从Botrytis cinerea中分离到norbotryal等。NAKAMURA测定了抗真菌抗生素neo-enactins的结构。他们的活动被评估。YAMAGUCHI通过使用野生型和突变型白色念珠菌的筛选系统寻找抗真菌抗生素，并分离出一种化合物。NATORI对磷芥（Phomopsis sp.）的代谢产物进行了研究，分离出多种胞沙三酸化合物。佐藤发现二乙基雌酚（DES）对微管组装的影响。研究了DES及其相关化合物的作用。NOZOE对担子菌的代谢产物进行了研究，并分离出几种抗生素。FUJITA对含-氨基异丁酸的肽进行了研究，并确定了它们的结构。OKUDA和IWASAKI分离了几种抗有丝分裂化合物，并研究了它们的作用方式。并设计了利用稻瘟霉进行筛选的系统。