Studies on Macrobial Metabolites Effective to Eucaryotic Cells

山崎分离得到了单胺氧化酶抑制剂EA-1、TA-1、TL-1和去甲酸，并对它们的特异性进行了鉴定。大村从放线菌的代谢物中寻找血小板聚集抑制剂，并在几种醌类抗生素中发现了这种活性，如梅德霉素和纳诺霉素。鉴定了一个新的同位素化合物OM-4842。铃木测定了N-乙酰孢霉亲和素的总结构和Auleximycin的部分结构。Mikami合成了一系列抗肿瘤抗生素沙拉霉素的衍生物，并对其构效关系进行了研究。Yamamoto寻找到了抗L5178Y细胞的化合物，从灰霉病菌中分离到了单烯类化合物，并从卡氏巨藻中分离到了单烯类化合物，从球藻中分离出了酪醇类化合物，还从灰霉病菌中分离到了酪醇类化合物。Nakamura测定了抗真菌抗生素neo-enactins的结构。评估了他们的活动。山口使用白色念珠菌的野生株和突变株的筛选系统搜索了抗真菌抗生素，并分离出了一种化合物。Natori对拟南星的代谢产物进行了研究，分离出了一系列松胞素类化合物。佐藤发现己烯雌酚(DES)对肌小管组装有影响。研究了DES及其相关化合物的作用。对担子菌的代谢产物进行了研究，并分离出了几种抗生素。藤田对含有氨基异丁酸的多肽成分进行了研究，确定了它们的结构。Okuda和Iwaaki分离得到了几种抗有丝分裂的化合物，并对其作用机制进行了研究。建立了稻瘟病菌筛选系统。

YAMAZAKI isolated monoamine oxidase oxidase inhibitors, EA-1, TA-1, TL-1 and norsolorinic acid, as the metaboltes Emericella navahoensis and Talaromyces lutens, and their specific sctivity was clarified. OMURA searched for pletelet aggregation inhibitors form the metaboltes of Actinomycetes, and found such activity in several quinone antibiotics such as medermycin and nanaomycin. A new isotetracenoid, OM-4842, was slso identified. SUZUKI determined the total structure of N-acetylsporaviridin and the partial atructure of aculeximycin. MIKAMI prepared a vriety of derivatives of saframycin, an antitumor antibiotic, and structure-activity relationship was studied. YAMAMOTO searched for anti-L5178Y cell compounds, and isolated monorden from Macrophoma castaneicola, tyrosol from Glomellera cingulate and norbotryal etc from Botrytis cinerea. NAKAMURA determined the structures of neo-enactins, antifungal antibiotics. Their activities were evaluated. YAMAGUCHI searched for antifungal antibiotics by a screening system using a wild type and a mutant strains of Candida albicans and isolated a compound. NATORI studied on the metabolites of Phomopsis sp., and isolated a varietyof cytochalasan compounds. SATO found that diethylstibestrol (DES) effects on myclotubule assembly. The action of DES and related compounds were studied. NOZOE studied on the metabolitesd of Basidiomycete, and isolated several antibiotics. FUJITA studied on the peptidic containing -amino-isobutylic acid as their components, and their structures were established. OKUDA and IWASAKI isolated several anti-mitotic compounds and their mode of action was studied. A screening system using Pyricularia oryzae was also deviced.