Modification of the microbiome and utilisation of microbial products as novel treatments for COPD
Modification of the microbiome and utilisation of microbial products as novel treatments for COPD
批准号:
nhmrc : 1059239
负责人:
Prof Matthew Cooper
金额:
$81.77万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2018-12-31
中文摘要
吸烟会导致肺部发炎,导致肺气肿--这是澳大利亚的一个主要健康问题。即使戒烟并且没有治疗方法,肺气肿也会逐渐减少。最近,肠道微生物的变化被认为与诱导或预防肠道和肺部炎症有关。因此,我们可能能够通过改变这些肠道微生物群来控制炎症。我们也许能够摄取特定的微生物,或者使用特定的抗生素或其他因素作为治疗肺气肿的新方法。
英文摘要
Smoking leads to lung inflammation that causes emphysema - a major health problem in Australia. Emphysema progressively declines even if smoking stops and there are no treatments. Recently changes in gut microbes have been linked to inducing or protecting against inflammation in the gut and lung. Thus we may be able to control inflammation by modifying these gut microbiomes. We may be able to ingest specific microbes or use specific antibiotics or other factors as new treatments for emphysema.
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