Disturbance of Integral of Cerebral Hemispheres in Fuvctional Psychoses

功能性精神病中大脑半球积分紊乱

• 批准号: 60304063
• 负责人: TAKAHASHI Ryo
• 金额: $ 7.04万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60304063/
• 关键词: Functional Psychoses; Integral Function of Cerebral Hemispheres; Neuropsychology; Eye Movements; Event-relsted Potential; CNV; Regional Blood Flow; MRI-CT; 脳局所血流; 核磁気共鳴脳断層撮影; 精神分裂病

DISTURBANCE OF INTEGRAL FUNCTION OF CEREBRAL HEMISPHERES IN FUNCTIONAL PSYCHOSES This project was conducted to clarify the disturbance of differential and integral functions of the cerebral hemisperse in functional psychoses using multi-dimentional methods. The relationships between right and left hemispheres as well as cortical and subcortical areas, and frontal and posterior regions were explored using neurophysiologicsl, psychophysiological, neuropsychological and morphological methods. Dr.Torii,H. explored the mirror writing and age desorientation in schizophrenia, Dr.Hozaki,H. distinguished schizophrenics from patients with frontal lobe lesion using the new modified Wisconsin Card Sorting Test.Dr.Okuma,T. showed the cerebral lateralization in functional psychosis measured by horizontal eye movements, Dr.Takahashi,R. examined the relationship between clinical symptoms and the tempo measuted by eye movements and he also studied the cerebral lateralization of eye fixations and moveme … More nts in temporal lobe spilepsy compared to focal sides of spikes.Dr.Takahashi, S. sutdied the interhemispheric dysgunction on verbal tasks in schizophrenia using CNV. Dr.Niwa showed event-related potential correlates of psychotropic drug effects on attentional and hemispheric dysfunction in schizophrenia. Dr.Machiyama,Y. also studied the event-related potential to clarify the topographic and temporal aspects of information processing abnormalities in schizophrenia. Dr.Yamaguchi,N.examined the regional blood flow in schizophrenics and depressed patients.Dr.Inanaga,K. examined morphological changes in the brains of schizophrenics using MRI-CT. From the view point of right and left hemispheric functions,most of our studies suggested thst schizophrenics had a left hemispheric dysfunction rather than the right one. The neurophysiological report suggested that the predominant side of cerebral hemispheric function was changeable according to the prognosis or types of schizophrenia such as a paranoid and a non-paranoid. Although the hypofrontality theory of schizophrenia is prevalent, the results obtained in our project were not consistent with the theory and suggested not only frontal lobe but aiso the other regions such as limbic system, thalamic muclei and basal ganglia may be involved to produce a schizophrenia.These collaborative studies had been done for 3 yesrd was very fruitful for the clarification of pathophysiological mechanism of schizophrenia. Less

功能性精神病患者大脑半球的整体功能障碍本研究采用多维方法对功能性精神病患者大脑半球的微积分功能障碍进行了研究。采用神经生理学、心理生理学、神经心理学和形态学等方法，对大脑左右半球、皮质和皮质下、额叶和后部的关系进行了研究。Torii，H.探索了精神分裂症的镜像书写和年龄迷失，Hozaki，H.使用新的改进的威斯康星卡片分类测验将精神分裂症患者与额叶病变的患者区分开来。Okuma，T.博士展示了通过水平眼球运动测量的功能性精神病的大脑偏侧化，Takahashi，R.博士研究了临床症状与眼球运动测量的节奏之间的关系，他还研究了眼睛注视和运动…的大脑偏侧化Takahashi，S.博士利用CNV研究了精神分裂症患者在言语任务上的大脑半球间功能障碍。Niwa博士展示了精神药物对精神分裂症患者注意力和大脑半球功能障碍的事件相关潜在影响。Mchiyama博士还研究了事件相关电位，以阐明精神分裂症患者信息处理异常的地形图和时间方面。山口博士研究了精神分裂症患者和抑郁症患者的局部血流。稻田博士利用MRI-CT检查了精神分裂症患者大脑的形态变化。从左右半球功能的角度来看，我们的大多数研究表明精神分裂症患者有左半球功能障碍，而不是右半球功能障碍。神经生理学报告表明，大脑半球功能的优势侧根据精神分裂症的预后或类型而变化，如偏执型和非偏执型。虽然精神分裂症的额下性理论很流行，但我们的研究结果与理论不符，提示精神分裂症不仅涉及额叶，还可能涉及边缘系统、丘脑、基底节等其他区域，这些合作研究已进行了3年，对于阐明精神分裂症的病理生理机制是非常有成效的。较少

项目成果

Yoshihiko Matsue;Teruo Okuma et al.: Biol Psychiatry. 21. 382-389 (1986)

Yoshihiko Matsue；Teruo Okuma 等：Biol Psychiatry。

鹿島 晴雄: 神経研究の進歩. 30. 847-858 (1986)

Haruo Kashima：神经学研究进展。30。847-858（1986）

Kashima, H.: "Disorders of attenticn due to grontal lobe lesion." Advances in Neurological Sciences. 30. 847-858 (1986)

Kashima, H.：“由于齿龈叶病变导致的注意力障碍。”

丹野義彦,町山幸輝: 臨床精神医学. 15. 53-62 (1986)

Yoshihiko Tanno，Yukiteru Machiyama：临床精神病学 15. 53-62 (1986)

Matsue, Y.: "Saccadic Eye Movements in Tracking,Fixation,and Rest in Schizophrenic and Nornal Subjects." 21. 382-389 (1986)

Matsue, Y.：“精神分裂症和正常受试者跟踪、注视和休息中的眼跳运动。”