Disturbance of Integral of Cerebral Hemispheres in Fuvctional Psychoses

功能性精神病中大脑半球积分紊乱

• 批准号: 60304063
• 负责人: TAKAHASHI Ryo
• 金额: $ 7.04万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60304063/
• 关键词: Functional Psychoses; Integral Function of Cerebral Hemispheres; Neuropsychology; Eye Movements; Event-relsted Potential; CNV; Regional Blood Flow; MRI-CT; 脳局所血流; 核磁気共鳴脳断層撮影; 精神分裂病

DISTURBANCE OF INTEGRAL FUNCTION OF CEREBRAL HEMISPHERES IN FUNCTIONAL PSYCHOSES This project was conducted to clarify the disturbance of differential and integral functions of the cerebral hemisperse in functional psychoses using multi-dimentional methods. The relationships between right and left hemispheres as well as cortical and subcortical areas, and frontal and posterior regions were explored using neurophysiologicsl, psychophysiological, neuropsychological and morphological methods. Dr.Torii,H. explored the mirror writing and age desorientation in schizophrenia, Dr.Hozaki,H. distinguished schizophrenics from patients with frontal lobe lesion using the new modified Wisconsin Card Sorting Test.Dr.Okuma,T. showed the cerebral lateralization in functional psychosis measured by horizontal eye movements, Dr.Takahashi,R. examined the relationship between clinical symptoms and the tempo measuted by eye movements and he also studied the cerebral lateralization of eye fixations and moveme … More nts in temporal lobe spilepsy compared to focal sides of spikes.Dr.Takahashi, S. sutdied the interhemispheric dysgunction on verbal tasks in schizophrenia using CNV. Dr.Niwa showed event-related potential correlates of psychotropic drug effects on attentional and hemispheric dysfunction in schizophrenia. Dr.Machiyama,Y. also studied the event-related potential to clarify the topographic and temporal aspects of information processing abnormalities in schizophrenia. Dr.Yamaguchi,N.examined the regional blood flow in schizophrenics and depressed patients.Dr.Inanaga,K. examined morphological changes in the brains of schizophrenics using MRI-CT. From the view point of right and left hemispheric functions,most of our studies suggested thst schizophrenics had a left hemispheric dysfunction rather than the right one. The neurophysiological report suggested that the predominant side of cerebral hemispheric function was changeable according to the prognosis or types of schizophrenia such as a paranoid and a non-paranoid. Although the hypofrontality theory of schizophrenia is prevalent, the results obtained in our project were not consistent with the theory and suggested not only frontal lobe but aiso the other regions such as limbic system, thalamic muclei and basal ganglia may be involved to produce a schizophrenia.These collaborative studies had been done for 3 yesrd was very fruitful for the clarification of pathophysiological mechanism of schizophrenia. Less

功能性精神病患者大脑半球积分功能障碍本课题采用多维度的研究方法，探讨功能性精神病患者大脑半球微分和积分功能障碍。用神经生理学、心理生理学、神经心理学和形态学方法探讨了左右半球、皮质区和皮质下区、额区和后区之间的关系。Torii博士，H.研究了精神分裂症患者的镜像书写和年龄定向障碍。使用新的改良威斯康星州卡片分类测验区分精神分裂症患者和额叶病变患者。通过水平眼球运动测量功能性精神病的大脑偏侧化。他研究了临床症状和眼球运动克里思之间的关系，他还研究了眼球固定和运动的大脑偏侧化。 ...更多信息 颞叶癫痫与病灶侧棘波的比较。应用CNV技术研究了精神分裂症患者在言语任务中的大脑半球间功能障碍。Niwa博士显示了精神药物对精神分裂症患者注意力和半球功能障碍的影响的事件相关潜在相关性。Machiyama，Y.还研究了事件相关电位，以阐明精神分裂症信息处理异常的地形和时间方面。山口博士检查了精神分裂症和抑郁症患者的局部血流。用磁共振CT检查精神分裂症患者大脑的形态学变化。从左右半球功能的角度来看，我们的研究大多认为精神分裂症患者存在左半球功能障碍而不是右半球功能障碍。神经生理学报告提示，大脑半球功能优势侧随精神分裂症的预后或类型（如偏执型和非偏执型）而改变。虽然精神分裂症的额叶功能减退学说很流行，但本课题的研究结果与该学说并不一致，提示精神分裂症的发生不仅与额叶有关，还与边缘系统、丘脑核、基底节等脑区有关，这些合作研究为阐明精神分裂症的病理生理机制取得了丰硕成果。少

项目成果

Yoshihiko Matsue;Teruo Okuma et al.: Biol Psychiatry. 21. 382-389 (1986)

Yoshihiko Matsue；Teruo Okuma 等：Biol Psychiatry。

鹿島 晴雄: 神経研究の進歩. 30. 847-858 (1986)

Haruo Kashima：神经学研究进展。30。847-858（1986）

Kashima, H.: "Disorders of attenticn due to grontal lobe lesion." Advances in Neurological Sciences. 30. 847-858 (1986)

Kashima, H.：“由于齿龈叶病变导致的注意力障碍。”

丹野義彦,町山幸輝: 臨床精神医学. 15. 53-62 (1986)

Yoshihiko Tanno，Yukiteru Machiyama：临床精神病学 15. 53-62 (1986)

Matsue, Y.: "Saccadic Eye Movements in Tracking,Fixation,and Rest in Schizophrenic and Nornal Subjects." 21. 382-389 (1986)

Matsue, Y.：“精神分裂症和正常受试者跟踪、注视和休息中的眼跳运动。”