Disturbance of Integral of Cerebral Hemispheres in Fuvctional Psychoses

功能性精神病的大脑半球整体功能障碍本项目旨在利用多维方法阐明功能性精神病的大脑半球微分和整体功能障碍。运用神经生理学、心理生理学、神经心理学和形态学等方法，探讨了左、右半球、皮层和皮层下区域、额叶和后叶区域之间的关系。Dr.Torii, H。探讨了精神分裂症患者的镜像书写和年龄定向障碍。使用新修改的威斯康星卡片分类测试来区分精神分裂症患者和额叶病变患者。通过水平眼动测量，发现功能性精神病患者大脑偏侧。他研究了临床症状和眼动速度之间的关系，他还研究了眼球注视和眼球运动的大脑偏侧。利用CNV研究了精神分裂症患者言语任务的脑内功能障碍。niwa博士展示了精神药物对精神分裂症患者注意力和半球功能障碍的影响与事件相关的潜在关联。Dr.Machiyama Y。还研究了事件相关电位，以澄清精神分裂症中信息加工异常的地形和时间方面。Dr.Yamaguchi, N。研究了精神分裂症患者和抑郁症患者的局部血流量。用核磁共振ct检查了精神分裂症患者大脑的形态变化。从左右半球功能的角度来看，我们的大多数研究表明，精神分裂症患者有左半球功能障碍，而不是右半球功能障碍。神经生理学报告表明，根据精神分裂症的预后或类型（如偏执型和非偏执型），大脑半球功能的优势侧是可变的。虽然精神分裂症的下额叶理论很流行，但本项目的研究结果与该理论并不一致，认为精神分裂症的发生不仅与额叶有关，还与边缘系统、丘脑核和基底神经节等其他区域有关。这些合作研究在阐明精神分裂症的病理生理机制方面取得了丰硕的成果。少

DISTURBANCE OF INTEGRAL FUNCTION OF CEREBRAL HEMISPHERES IN FUNCTIONAL PSYCHOSES This project was conducted to clarify the disturbance of differential and integral functions of the cerebral hemisperse in functional psychoses using multi-dimentional methods. The relationships between right and left hemispheres as well as cortical and subcortical areas, and frontal and posterior regions were explored using neurophysiologicsl, psychophysiological, neuropsychological and morphological methods. Dr.Torii,H. explored the mirror writing and age desorientation in schizophrenia, Dr.Hozaki,H. distinguished schizophrenics from patients with frontal lobe lesion using the new modified Wisconsin Card Sorting Test.Dr.Okuma,T. showed the cerebral lateralization in functional psychosis measured by horizontal eye movements, Dr.Takahashi,R. examined the relationship between clinical symptoms and the tempo measuted by eye movements and he also studied the cerebral lateralization of eye fixations and moveme … More nts in temporal lobe spilepsy compared to focal sides of spikes.Dr.Takahashi, S. sutdied the interhemispheric dysgunction on verbal tasks in schizophrenia using CNV. Dr.Niwa showed event-related potential correlates of psychotropic drug effects on attentional and hemispheric dysfunction in schizophrenia. Dr.Machiyama,Y. also studied the event-related potential to clarify the topographic and temporal aspects of information processing abnormalities in schizophrenia. Dr.Yamaguchi,N.examined the regional blood flow in schizophrenics and depressed patients.Dr.Inanaga,K. examined morphological changes in the brains of schizophrenics using MRI-CT. From the view point of right and left hemispheric functions,most of our studies suggested thst schizophrenics had a left hemispheric dysfunction rather than the right one. The neurophysiological report suggested that the predominant side of cerebral hemispheric function was changeable according to the prognosis or types of schizophrenia such as a paranoid and a non-paranoid. Although the hypofrontality theory of schizophrenia is prevalent, the results obtained in our project were not consistent with the theory and suggested not only frontal lobe but aiso the other regions such as limbic system, thalamic muclei and basal ganglia may be involved to produce a schizophrenia.These collaborative studies had been done for 3 yesrd was very fruitful for the clarification of pathophysiological mechanism of schizophrenia. Less