Study on interactions of Nervous and humoral factors on the regulation of respiratory and cardiovascular systems.

机体的自主神经功能是通过自主神经系统和体液因素如交感神经系统来调节的，它们之间存在着相互作用。本项目研究神经因子和体液因子的相互作用对呼吸和心血管系统的调节作用。实验中使用麻醉的兔子和狗。通过插入股动脉的导管进行快速出血，以刺激压力感受器。连续监测肾交感神经活动和动脉P和PC以及呼吸运动。<O_2><O_2>本研究测定了急性失血前后不同时间血液中肾上腺素和去甲肾上腺素的含量。动脉快速出血引起的动脉压下降在1~2分钟内不仅通过神经活动的增加，而且通过神经活动的增加来调节。 ...更多信息 儿茶酚胺分泌物。结果表明：（1）压力感受器刺激可引起快速动脉阻断后1~2min内P升高和PC降低，并抑制自主神经活动;（2）压力感受器刺激可引起快速动脉阻断后1~2min内P升高和PC降低。<O_2><O_2>自主神经活动的增加与动脉压下降的幅度相比是较小的，这一结果是由于（1）伴随着儿茶酚胺含量的增加，它可能抑制交感神经活动。(2)P增加，PC减少，使活性降低。<O_2><O_2>(3)本实验中使用的麻醉剂对神经系统本身或心血管系统的受体和效应器的抑制作用。在上一个项目年度，使用未麻醉的动物进行自主神经功能的研究在方法上取得了进展。在狗中常规地长时间（在约一个月期间）实现肾神经活动的有意识记录的成功。少

Autonomic functions of the body are regulated both through the autonomic nervous system and humoral factors such as hormons, and there are interactions between them. In this project, the interactions of neuronal and humoral factors was studied on the regulations of the respiratory and cardiovascular systems. Anesthetized rabbits and dogs were used in the experiments. Rapid hemorrhage through the catheter inserted into the femoral artery was done for the stimulation of the baroreceptors. Renal sympathetic nerve activities and arterial P <O_2> and PC <O_2> together with respiratory movements were monitored continuously. Catecholamine contents(adrenalin and noradrenalin) in the bood were measured at certain interval of time before and after the rapid hemorrhage.The results of the study are as follows ;1. Arterial pressure drop by the rapid arterial hemorrhage was regulated between 1 and 2 min thereafter not only through the increase in nerve activities but also through the increase in the … More catecholamine secretions. It was suggested by the experiments of the afferent denervation that there was increase in catecholamine secretions through some mechanisms to greater extents other than that as transmitters.2.Stimulations of baroreceptors induced increase in P <O_2> and decreace in PC <O_2> through the increments of respiratory movements and suppressed the autonomic nervous activities during 1 to 2 min after rapid arterial hemorrhage.3. Increase in the autonomic nervous activities was less in comparison to the magnitude of the arterial pressure drop.This result was due to (1) concomittant increase in the catecholamine contents which may inhibit the sympathetic activities. (2) Increased P <O_2> and decreased PC <O_2> which lowered the activites. (3) Inhibitory effects of the anesthetics used in this experiments on the nervous system itself or the receptors and effectors of the cardiovascular systems. Methodological advances were attained in the last project year to use the unanesthetized animals for the study of the autonomic functions. A success of the conscious recording of the renal nerve activities was routinely achieved in the dogs for a long period of time( during about one month). Less