The central or peripheral effects of atrial natriuretic peptide on the renin-angiotensin-aldosterone system, vasopressin release, and renal functions.

心钠素对肾素-血管紧张素-醛固酮系统、加压素释放和肾功能的中枢或外周作用。

• 批准号: 60570380
• 负责人: KIMURA Tokihisa
• 金额: $ 1.09万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570380/
• 关键词: atrial natriuretic peptide; renin; vasopressin; natriuresis; diuresis; レニン-アンギオテンシン; アルドステロン

In order to investigate effects of centrally or peripherally administered atrial natriuretic peptide (ANP) on the renin-angiotensin-aldosterone system, vasopressin (AVP) release and renal function, experiments were carried out in dogs with anesthetized with pentobarbital. <alpha> -hANP (human ANP) was administered intracerebroventricularly (icv) or systematically. Moreover, to assess the mutual relationship between ANP and AVP in man, the sensitive radioimmunoassay for human ANP was developed and plasma AVP and ANP levels were simultaneously determined under various hydrational states.1) Effects of human atrial natriuretic peptide on renal function and vasopressin release: Systemic infusion of <alpha> -hANP (0.08 <micro> g・ <Kg^(-1)> ・ <min^(-1)> ) for 40 min caused a natriuresis and kaliuresis with a significant increase in renal blood flow (RBF) without changes in glomerular filtration rate (GFR) despite a decrease in mean arterial blood pressure (MABP). Plasma renin activity (PRA), … More aldosterone concentration (PAC) and AVP concentration were not changed significantly throughout the study. Therefore, it is concluded that ANP may increase RBF or affect directly the renal tubules, leading to a natriuresis.2) Effects of centrally administered atrial natriuretic peptide on renal function: <alpha> -hANP given icv (8 ng・ <Kg^(-1)> ・ <min^(-1)> ) for 30 min caused a natriuresis and kaliuresis associated with a rise in RBF and a fall in plasma AVP, but plasma <alpha> -hANP, PRA and PAC and MABP were not change significantly. These results suggest that ANP in the brain may participate in the regulation of renal water and electrolyte handling via the unknown mechanisms.3) Effects of acute water load, hypertonic saline infusion, and furosemide administration on atrial natriuretic peptide and vasopressin releases in humans: Plasma <alpha> -hANP rose in response to the expansion of plasma volume due to acute water load or hypertonic saline infusion and fell due to the contraction of plasma volume. AVP was changed mainly in response to changes in plasma osmolality. Less

为了研究心房利钠肽（ANP）对戊巴比妥麻醉犬肾素-血管紧张素-醛固酮系统、抗利尿素（AVP）释放及肾功能的影响。< α > -hANP（人ANP）经脑室内（icv）或系统给予。此外，为了评估ANP和AVP在人体内的相互关系，我们建立了灵敏的人ANP放射免疫测定法，同时测定了不同水合状态下血浆AVP和ANP的水平。1)人心房利钠肽对肾功能和抗利尿素释放的影响：全身输注< α - > -hANP(0.08 <微> g·<Kg^(-1)>·<min^(-1)>) 40分钟引起尿钠和钾尿，肾血流量（RBF）显著增加，但平均动脉血压（MABP）降低，肾小球滤过率（GFR）未发生变化。血浆肾素活性（PRA）、More醛固酮浓度（PAC）和AVP浓度在整个研究过程中均无显著变化。因此，ANP可能增加RBF或直接影响肾小管，导致尿钠。2)心房利钠肽对肾功能的影响：< α - > -hANP给予icv (8 ng·<Kg^（-1)>·<min^(-1)>）治疗30 min引起尿钠和钾尿，RBF升高，血浆AVP下降，但血浆< α - > -hANP、PRA、PAC和MABP无显著变化。这些结果提示，脑内ANP可能通过未知的机制参与肾脏水电解质处理的调节。3)急性水负荷、高渗生理盐水输注和速尿对人心房利钠肽和抗利尿素释放的影响：血浆< α > -hANP随着急性水负荷或高渗生理盐水输注引起血浆容量的扩大而升高，随着血浆容量的收缩而下降。AVP的改变主要与血浆渗透压的变化有关。少

项目成果

Tokihisa Kimura: Brain and Blood Pressure Control. (1986)

Tokihisa Kimura：大脑和血压控制。

Kuniaki Matsui: Am.J.Physiol.252. R***-R*** (1987)

松井国明：Am.J.Physiol.252。

Kuniaki Matsui: "Resistance of 1-Deamino[8-D-Arginine]-Vasopressin to in Vitro Degradation as Compared with Arginine Vasopressin." Endocrinol. Japon.32. 547-557 (1985)

Kuniaki Matsui：“与精氨酸加压素相比，1-脱氨基[8-D-精氨酸]-加压素对体外降解的抵抗力。”

Tokihisa Kimura: "The Presence of Methionine-Enkephalin in Plasma and Urine in Normal Human Subjects and Various Patients." Endocrinol. Japon.32. 517-527 (1985)

Tokihisa Kimura：“正常人类受试者和各种患者的血浆和尿液中存在蛋氨酸脑啡肽。”

Tokihisa Kimura: Am.J.Physiol.250. R789-R794 (1985)

木村时久：Am.J.Physiol.250。