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Effects of interleukin-1beta on the release of AVP, ANP, and ACTH, cardiovascular function and thermogenesis.

IL-1β 对 AVP、ANP 和 ACTH 释放、心血管功能和生热作用的影响。

基本信息

批准号：
04454260
负责人：
KIMURA Tokihisa
金额：
$ 3.46万
依托单位：
Tohoku University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454260/
关键词：
Cytokine Nitric Oxide Vasopressin ANP Blood Pressure Temperature Steroid Hormone Prostaglandin 副賢皮質刺激ホルモン

项目摘要

1. Central effects of interleukin-1beta on blood pressure, thermogenesis and the release of vasopressin, ACTH and atrial natriuretic peptide. Interleukin 1-beta (IL-1beta) increased plasma vasopressin (AVP), ACTH and atrial natriuretic peptide (ANP). IL-1beta in the low dose (3-30 ng ・ 100g^<-1> ・ BW) increased body temperature (BT) and blood pressure (BP), but its high dose (150 ng ・ 100g^<-1> ・ BW) depressed them. Indomethacin, a cycloxygenase inhibitor, prevented the responses to IL-1beta except for increases in ANP release.2. Peripheral Effects of interleukin-1beta on blood pressure, themoregulation and the release of vasopressin, ACTH and atrial natriuretichormones. IL-1beta given iv stimulated the release of AVP, ACTH, and ANP and increased or decreased blood pressure and thermogenesis. Indomethacin attenuatted all these responses to IL-1beta except for increases in ANP.3. Effects of a nitric oxide synthase inhibitor (LNAME) on vasopressin and atrial natriuretic hormone releaase, thermogenesis and cardiovascular function in response to interleukin-1beta in rats. LNAME stimulted the release of AVP and ANP and body temperature and blood pressure. NO formed by IL-1beta may not have direct effects on the release of these hormones, and the regulation of body temperature, but decreased transiently blood pressure.4. Roles of atrial natriuretic peptide in an interleukin-1beta-induced natriuresis in conscious rats. IL-1beta brought about a natriuresis in accordance with increased plasma ANP and the specific ANP receptor antagonist "HS 142-1" prevented the natriuresis induced by IL-1beta, despite increased plasma ANP.

1.白细胞介素-1 β对血压、产热和血管加压素、促肾上腺皮质激素和心钠素释放的中枢作用白细胞介素1-β（IL-1 β）增加血浆加压素（AVP）、促肾上腺皮质激素（ACTH）和心钠素（ANP）。低剂量（3-30 ng ·100 g ^ · BW）IL-1 β<-1>可使体温（BT）和血压（BP）升高，而高剂量（150 ng ·100 g ^<-1>· BW）则使体温和血压降低。环氧化酶抑制剂吲哚美辛可抑制IL-1 β的反应，但增加ANP的释放.白细胞介素-1 β对血压、热调节和血管加压素、ACTH和心房利钠素释放的外周效应iv IL-1 β刺激AVP、ACTH和ANP的释放，升高或降低血压和产热。吲哚美辛减弱了IL-1 β对所有这些反应，但增加了ANP。一氧化氮合酶抑制剂（LNAME）对白细胞介素-1 β诱导的大鼠血管加压素和心钠素释放酶、产热和心血管功能的影响LNAME可促进AVP和ANP的释放，并增加体温和血压。IL-1 β形成的NO可能对这些激素的释放，以及体温的调节没有直接的作用，但具有一过性的降压作用.心房利钠肽在白细胞介素1 β诱导清醒大鼠尿钠排泄中的作用。IL-1 β引起的尿钠排泄与血浆心钠素水平的升高一致，而特异性心钠素受体拮抗剂HS 142-1则可阻止IL-1 β引起的尿钠排泄，尽管血浆心钠素水平升高。