Effects of interleukin-1beta on the release of AVP, ANP, and ACTH, cardiovascular function and thermogenesis.

1.白细胞介素的中央效应-1beta对血液压力、热生成和血管紧张素、ACTH和大气自然肽的释放。白细胞介素1-beta（IL-1 beta）增强等离子体血管紧张素（AVP）、ACTH和atrial natriuretic肽（ANP）。IL-1 beta in the low dose （3-30 ng ·100 g ^<-1> · BW）增加身体温度（BT）和血液压力（BP），但其高剂量（150 ng ·100 g ^<-1> · BW）被压抑。Indomethacin，一种环氧酶抑制剂，预防了对IL-1测试版的反应，以增加ANP释放中的IL-1。白细胞介素的外围效应-1测试版对血液压力、术语测定和血管紧张素、ACTH和大气自然色素的释放。IL-1测试版IV刺激了AVP、ACTH和ANP的释放，以及增加或减少的血液压力和热生成。Indomethacin注意到了所有这些反应，除了在ANP.3中增加的IL-1测试版。硝酸氧化物合成酶抑制剂（LNAME）对血管紧张素和atriuretic激素释放、热生成和心血管功能对大鼠中的干扰素-1 beta的反应的影响。LNAME刺激了AVP和ANP的释放以及身体温度和血液压力。没有IL-1测试版的形式可能对这些荷尔蒙的释放没有直接影响，以及身体温度的调节，但没有明显的瞬态血液压力。在肠梗阻中的atririuretic肽的作用--1 beta-induced natriuresis在意识老鼠中。“使用increased plasma ANP和特定ANP受体antagonist”HS 142-1“prevented the natriuresis induced by IL-1 beta， despite increased plasma ANP。

1. Central effects of interleukin-1beta on blood pressure, thermogenesis and the release of vasopressin, ACTH and atrial natriuretic peptide. Interleukin 1-beta (IL-1beta) increased plasma vasopressin (AVP), ACTH and atrial natriuretic peptide (ANP). IL-1beta in the low dose (3-30 ng ・ 100g^<-1> ・ BW) increased body temperature (BT) and blood pressure (BP), but its high dose (150 ng ・ 100g^<-1> ・ BW) depressed them. Indomethacin, a cycloxygenase inhibitor, prevented the responses to IL-1beta except for increases in ANP release.2. Peripheral Effects of interleukin-1beta on blood pressure, themoregulation and the release of vasopressin, ACTH and atrial natriuretichormones. IL-1beta given iv stimulated the release of AVP, ACTH, and ANP and increased or decreased blood pressure and thermogenesis. Indomethacin attenuatted all these responses to IL-1beta except for increases in ANP.3. Effects of a nitric oxide synthase inhibitor (LNAME) on vasopressin and atrial natriuretic hormone releaase, thermogenesis and cardiovascular function in response to interleukin-1beta in rats. LNAME stimulted the release of AVP and ANP and body temperature and blood pressure. NO formed by IL-1beta may not have direct effects on the release of these hormones, and the regulation of body temperature, but decreased transiently blood pressure.4. Roles of atrial natriuretic peptide in an interleukin-1beta-induced natriuresis in conscious rats. IL-1beta brought about a natriuresis in accordance with increased plasma ANP and the specific ANP receptor antagonist "HS 142-1" prevented the natriuresis induced by IL-1beta, despite increased plasma ANP.