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Psychophysiological Diagnosis of Depression : Determination of Diagnostic Criteria in Comparison with Other Major Mental Disorders

抑郁症的心理生理学诊断：与其他主要精神障碍比较诊断标准的确定

基本信息

批准号：
60570499
负责人：
NAKAMURA Michihiko
金额：
$ 1.02万
依托单位：
Psychiatric Research Institute of Tokyo (1986)Shiga University of Medical Science (1985)
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570499/
关键词：
Mental Disorder Depression Schizophrenia Hysteria CNV Diagnosis Classification 病態生理

项目摘要

1. Psychopathological Classification of Depression(1985)Depression was physiologically classified on the basis of the DSM-III. The bipolar and melancholic patients were significantly different in the CNV measures from the others so that the CNV was concluded to be a possible aid for classifying the depression with some accuracy. The cluster analysis using the CNV measures could reveal 3 or 4 subcategories, some corresponding with the bipolar and melancholic depressions. It was suggested on the basis of the inverted-U relation between the CNV and the extraversion score(cortical arousal level) of the Maudsley Personality Inventory that the bipolar patients may be hypoarousal in contrast with that the melancholiacs may be hyperarousal.2. Diagnosis of Depression Compared with Other Mental Disorders(1986)A hundred and five normals, 70 major depressive patients, 33 schizophrenics, and 14 hysterical patients with the Somatoform and Dissociative Disorders, all of whom were diagnosed according to the DSM-III, participated in the CNV study. The depressives could not be distinguished from the normals by the CNV magnitude but they had significantly larger CNV than the schizophrenic and hysterical patients. The whole patients were categorized into 2 groups by the cluster analysis regardless of their clinical diagnoses. Almost all patients of the first group were mainly depressed though their CNV magnitude ranged within the normal limits. The second group, symptomatically mixed, showed abnormally reduced CNV magnitude. The results suggest that the depression is pathophysiologically heterogeneous though they were diagnosed by the distinct criteria of the DSM-III and thus that the psychophysiological methods are usefull for evaluating the psychiatric patients. Furthermore, the discrimination analysis induced a function whichi could differentiate 2 kinds of mental disorder, reactive-mild form and intrinsic-severe form.

1.抑郁症的心理病理学分类(1985)抑郁症是根据DSM-III进行生理学分类的。双相情感障碍和忧郁症患者的 CNV 测量值与其他患者显着不同，因此得出结论，CNV 可能有助于以一定的准确性对抑郁症进行分类。使用 CNV 测量的聚类分析可以揭示 3 或 4 个子类别，其中一些与双相抑郁和忧郁抑郁症相对应。根据CNV与Maudsley人格量表的外向性评分（皮质唤醒水平）之间的倒U关系，提出双相情感障碍患者可能是低唤醒的，而忧郁症患者可能是高唤醒的。 2．抑郁症与其他精神障碍的诊断比较(1986) 105名正常人、70名重度抑郁症患者、33名精神分裂症患者和14名患有躯体形式障碍和解离障碍的癔症患者参加了CNV研究，所有这些患者均根据DSM-III进行诊断。抑郁症患者无法通过 CNV 大小与正常人区分开来，但他们的 CNV 明显大于精神分裂症和癔症患者。无论临床诊断如何，通过聚类分析将所有患者分为 2 组。尽管第一组的所有患者的 CNV 幅度都在正常范围内，但几乎所有患者都以抑郁为主。第二组症状混合，表现出 CNV 强度异常降低。结果表明，尽管抑郁症是按照 DSM-III 的不同标准诊断的，但其病理生理学上是异质的，因此心理生理学方法可用于评估精神病患者。此外，辨别分析还引入了区分两种精神障碍的功能：反应性轻度型和内在性重度型。