Normal and abnormal motor function of human sphincter of Oddi

人类奥迪括约肌正常和异常运动功能

• 批准号: 60570615
• 负责人: HADA Ryukichi
• 金额: $ 0.9万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570615/
• 关键词: sphincter of Oddi; gallbladder contraction; plasma CCK concentration; hydraulic-capillary; infusion system; pressure catheter transducer; migrating motor complex; CCK血中濃度

An evaluation of the motility of the sphincter of Oddi (SO) is important to diagnose whether a pathologic condition at the choledochoduodenal junction is of a functional or organic variety. For a basic knowledge about the motor function of the SO, we conducted a clinical research works.1) Manometric apparatus and Measurement of Motor Function of the Sphincter of Oddi: We developed a simple and easy-for-use infusion system that consisted of a ordinary i.v. pump connected with a high resistance check valve for arterial manometry (Intralfo). The performance of the system in the SO manometry was comparable to hydraulic-capillary infusion system or pressure catheter transducer. The infusion catheter was best settled via PTCD route. This method made a harmless long-lasting manometric study possible.2) CCK Administration and Motility of the Sphincter of Oddi: An intravenous dosage of 0.2-0.3 U/Kg/min of CCK-33for 10 min enhanced the plasma CCK level up to 30-50 pg/ml (control: below 7.5). at … More 8 to 10 min after the commencement of the intravenous CCK-33. The SO motor activities, both contractile force and frequency, were markedly suppressed to as low as 10-0 % of the control values. The suppression lasted for nearly 15 min. While, the gallbladder (GB) contracted strongly with a maximal contraction at 15-20 min after the beginning of CCK-33. It was concluded that reciprocal responses of the SO and GB to CCK yield and effective driving force for bile discharge.3) Motility of the Sphincter of Oddi during Interdigestive State: The SO motor activity was simultaneously registered with that of the duodenum. Although not consistently observed, the SO contracted 3-4/min even in the period of duodenal phase I, showing that the SO motor activity may be, fundamentally, independent of that of the duodenum. During duodenal phase II and II, the SO contractions were temporarily highly linked to the duodenal contractions with a frequency of 10-12/min. We concluded that fasting state, digestive or interdigestive, must be clearly documented when we refer to or evaluate the motor function of the SO and that a simultaneous recording of the duodenal motor activity is mandatory when we determine the SO motor function. Less

评价奥狄氏括约肌（SO）的能动性对于诊断胆总管十二指肠连接处的病理状态是功能性的还是器质性的是很重要的。为了了解SO运动功能的基本知识，我们进行了临床研究工作。1）Oddi括约肌的测压装置和运动功能测量：我们开发了一种简单易用的输液系统，由普通静脉泵组成。连接用于动脉测压的高阻单向阀（Intralfo）。该系统在SO测压中的性能与液压毛细管输注系统或压力导管传感器相当。输注导管最好通过PTCD途径固定。2）CCK-33的给药和Oddi括约肌的运动：静脉注射CCK-33 0.2-0.3 U/Kg/min，持续10 min，可使血浆CCK水平升高至30-50 pg/ml（对照组：低于7.5）。在 ...更多信息 静脉注射CCK-33后8 - 10分钟。SO运动活动（收缩力和频率）明显抑制至对照值的10- 0%。胆囊（GB）收缩强烈，在CCK-33开始后15-20 min收缩最大。结论：SO和GB对CCK的相互反应产生了胆汁排出的有效驱动力。3）消化间期Oddi括约肌的运动：SO的运动与十二指肠的运动同步。虽然没有一致的观察，SO收缩3-4/分钟，即使在十二指肠I期，表明SO运动活动可能是，从根本上说，独立的十二指肠。在十二指肠第二和第二阶段，SO收缩暂时高度相关的十二指肠收缩的频率为10-12/min。我们的结论是，空腹状态，消化或消化间期，必须清楚地记录时，我们提到或评估的SO运动功能，同时记录的十二指肠运动活动是强制性的，当我们确定SO运动功能。少

项目成果

K.Ono: Jap.J.Smooth Muscle Res.21(Suppl). 69-75 (1985)

K.Ono：Jap.J.Smooth Muscle Res.21（增刊）。

H. Suzuki,: "Bile discharge mechanism - motor activities of the sphincter of Oddi and duodenum" Jap. J. Smooth Muscle Res.22. 385-388 (1986)

H. Suzuki，：“胆汁排出机制 - Oddi 括约肌和十二指肠的运动活动”Jap。

R. Hada,: "Sphincter of Oddi manometry by means of pressure catheter transduser (MIKRO-TIP)" The Journal of Japan Society for Bilo-Pancreatic Physiology. 1. 1-6 (1985)

R. Hada，：“通过压力导管转导器 (MIKRO-TIP) 进行 Oddi 括约肌测压”，日本胆胰生理学会杂志。

Ono,: "Gastrointestinal hormones and motility of the human sphincter of Oddi" Jap. J. Smooth Muscle Res.21(Suppl). 69-75 (1985)

小野，：“胃肠激素和人类奥迪括约肌的运动”日本。

H. Suzuki,: "The effect of exogenous and endogenous CCK on the motor activities of the sphincter of Oddi, gallbladder and duodenum" The Journal of Japan Society for Bilo-Pancreatic Physiology. 2. 45-51 (1986)

H. Suzuki，：“外源性和内源性 CCK 对 Oddi 括约肌、胆囊和十二指肠运动活动的影响”日本胆胰生理学学会杂志。