Priliminary study to develop a perineal artificial anus

[目的]评价结肠造口段的昼夜运动特征。[方法]在9只狗的结肠上等距离放置4个力传感器(FT_&lt；1~4&gt；)，在回肠末端放置另一个力传感器，以区分消化间期。饲喂20g/kg或10g/kg膳食以改变消化期的持续时间，并进行24次记录。将收缩爆发的持续时间(收缩状态，CS)和每个运动静止状态(QS)的长度与餐后时间进行对比。[结果]20和10g/kg餐后，正常犬各FT时CS无明显变化，QS在2~4h缩短，15.3Sy开始显著增加。-.[]0.3h，20g/kg粉，11.5(]sy。-.[)0.8h，配餐10g。QS延长的出现与回肠MMC的出现密切相关(r=0.001.95~0.92，P<0.0 1)。在造口犬中，口腔结肠的运动曲线与造口前相同，而远端结肠的消化间期QS无延长。相反，CS和QS以4.7(]sy)的固定周期周期性地复发。-.[)CS为0.1分钟，SY为32.6分钟。-.[结论]QS的延长与消化间期的开始在时间上是锁定的。肠道连续性对于QS延长发生在整个结肠是必不可少的。结肠的每一段都可能有自己的收缩节律，而这一节律是由更接近的相邻节段(松弛振荡器)的节律所驱动的。

[AIM] To assess the diurnal motor profile in colostomized segment[METHODS] Four force transducers (FT_<1-4>) were implanted on the colon of 9 dogs at an equidistance and another FT on the terminal ileum to distinguish the digestive from interdigestive phase. The dogs were fed either 20 or 10 g/kg meal to modify the duration of the digestive phase and a 24 recording was performed. The duration of a contraction burst (contractile state, CS) and the length of each motor quiescent state (QS) were plotted against postprandial time. Later the colon was transected between FT_2 and FT_3 to establish a double-barrelled colostomy and a 24 h recording was resumed.[RESULTS] In the intact dogs with either 20 or 10 g/kg meal, CS at each FT did not change significantly, while QS shortened at 2-4 h and began to significantly increase at 15.3(]SY.+-。[)0.3 h with 20 g/kg meal and at 11.5(]SY.+-。[)0.8 h with 10 g meal. The onset of this QS prolongation was closely correlated with the appearance of the first ileal MMC (r=0.95-0.92, p<0.001). In the colostomized dogs, the motor profile in the oral colon was identical to that before colostomy, while no prolongation of QS in the interdigestive phase occurred in the distal colon. Instead, CS and QS recurred periodically with a fixed cycle of 4.7(]SY.+-。[)0.1 min for CS and 32.6(]SY.+-。[)1.8 min for QS,respectively.[CONCLUSION] Prolongation of QS is temporally locked with the beginning of the interdigestive phase. Bowel continuity is essential for this QS prolongation to occur throughout the colon. Each segment of the colon may have its own contractile rhythm which is entrained by the rhythm in a more proximal adjacent segment (relaxation oscillator).