Priliminary study to develop a perineal artificial anus

会阴人工肛门开发的初步研究

• 批准号: 07671351
• 负责人: HADA Ryukichi
• 金额: $ 0.96万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671351/
• 关键词: colonic motility; colostomy; colonic diurnal motor change; relaxation oscillator; relaxation oscillator; 人工肛門; 人工肛門周囲皮膚障害; 離断結腸運動日内変化; 人工括約装置; 会陰部人工肛門

[AIM] To assess the diurnal motor profile in colostomized segment[METHODS] Four force transducers (FT_<1-4>) were implanted on the colon of 9 dogs at an equidistance and another FT on the terminal ileum to distinguish the digestive from interdigestive phase. The dogs were fed either 20 or 10 g/kg meal to modify the duration of the digestive phase and a 24 recording was performed. The duration of a contraction burst (contractile state, CS) and the length of each motor quiescent state (QS) were plotted against postprandial time. Later the colon was transected between FT_2 and FT_3 to establish a double-barrelled colostomy and a 24 h recording was resumed.[RESULTS] In the intact dogs with either 20 or 10 g/kg meal, CS at each FT did not change significantly, while QS shortened at 2-4 h and began to significantly increase at 15.3(]SY.+-。[)0.3 h with 20 g/kg meal and at 11.5(]SY.+-。[)0.8 h with 10 g meal. The onset of this QS prolongation was closely correlated with the appearance of the first ileal MMC (r=0.95-0.92, p<0.001). In the colostomized dogs, the motor profile in the oral colon was identical to that before colostomy, while no prolongation of QS in the interdigestive phase occurred in the distal colon. Instead, CS and QS recurred periodically with a fixed cycle of 4.7(]SY.+-。[)0.1 min for CS and 32.6(]SY.+-。[)1.8 min for QS,respectively.[CONCLUSION] Prolongation of QS is temporally locked with the beginning of the interdigestive phase. Bowel continuity is essential for this QS prolongation to occur throughout the colon. Each segment of the colon may have its own contractile rhythm which is entrained by the rhythm in a more proximal adjacent segment (relaxation oscillator).

[AIM][方法]将4个力传感器（FT_<1-4>）等距离植入9只犬结肠，另1个力传感器植入回肠末端，以区分消化期和消化间期。给犬喂食20或10 g/kg膳食，以改变消化期的持续时间，并进行24小时记录。将收缩爆发的持续时间（收缩状态，CS）和每个运动静止状态（QS）的长度相对于餐后时间作图。随后，在FT_2和FT_3之间横切结肠以建立双管结肠造口术，并恢复24小时记录。[结果]正常犬20或10 g/kg膳食时，各FT时CS无明显变化，QS在2-4 h缩短，15.3（± SD）时开始显著增加; [)0.3 20 g/kg饲料组和11.5（±）SY. [)0.8 h，每餐10克。这种QS延长的开始与第一次回肠MMC的出现密切相关（r=0.95-0.92，p&lt;0.001）。在结肠造口犬中，口结肠的运动曲线与结肠造口前相同，而远端结肠在消化间期没有出现QS延长。相反，CS和QS以4.7（]SY ±）的固定周期性地重复。[)0.1 CS和32.6（± SD）min。[)1.8 QS分别为min。[结论] QS的延长与消化间期的开始有时间上的锁定。肠道连续性对于整个结肠的QS延长至关重要。结肠的每个节段可以具有其自己的收缩节律，该收缩节律由更近端的相邻节段中的节律（弛张振荡器）携带。

项目成果

Hada R et al: "Colonic motor response to varied amount of meal in intact and colostomied dogs" Gut. 39. 135-135 (1996)

Hada R 等人：“完整狗和结肠造口狗对不同膳食量的结肠运动反应”Gut。

Hada R et al: "Colonic motor response to varied amount of meal in intact and colostomied dogs." Gastroenterology. 110. A674 (1996)

Hada R 等人：“完整狗和结肠造口狗对不同膳食量的结肠运动反应。”

Hada R et al: "Diurnal motor change in canine colostomized segment" Gut. 39. A135 (1996)

Hada R 等人：“犬结肠造口段的昼夜运动变化”Gut。

Hada R et al: "Colonic motor response to varied amount of meal in intact and colostomied dogs" Gastroenterology. 110. 674-674 (1996)

Hada R 等人：“完整狗和结肠造口狗对不同膳食量的结肠运动反应”胃肠病学。

Hada R,Wajima N,et al: "Colonic motor response to varied amount of meal in intact and colostomied dogs" Gastroenterology. 110. A674 (1996)

Hada R、Wajima N 等人：“完整和结肠造口狗对不同膳食量的结肠运动反应”胃肠病学。