Priliminary study to develop a perineal artificial anus

[目的]评估结肠造口段的昼夜运动特征[方法]在9只犬的结肠上等距离植入4个力传感器(FT_<1-4>)，在回肠末端植入另一个FT，以区分消化期和消化间期。给狗喂食 20 或 10 g/kg 的食物，以改变消化阶段的持续时间，并进行 24 次记录。根据餐后时间绘制爆发性收缩的持续时间（收缩状态，CS）和每个运动静止状态（QS）的长度。随后在 FT_2 和 FT_3 之间横切结肠，建立双筒结肠造口，并恢复 24 h 记录。 [结果] 在 20 或 10 g/kg 膳食的完整犬中，每次 FT 时的 CS 没有显着变化，而 QS 在 2-4 h 缩短，并在 15.3(]SY.-。[)0.3 h 20 g/kg 膳食和11.5(]SY.-。[)0.8小时，10克膳食。 QS 延长的发生与第一回肠 MMC 的出现密切相关（r=0.95-0.92，p<0.001）。在接受结肠造口的狗中，口腔结肠的运动特征与结肠造口前相同，而远端结肠消化间期的 QS 没有延长。相反，CS 和 QS 周期性地重复，固定周期分别为 4.7(]SY.-。[)0.1 分钟（CS）和 32.6(]SY.-。[)1.8 分钟（QS）。[结论] QS 的延长在时间上与消化间期的开始锁定。肠道连续性对于整个结肠中 QS 延长至关重要。结肠的每个节段可能有其自己的收缩节律，该节律受到更近端的相邻节段（松弛振荡器）中的节律的影响。

[AIM] To assess the diurnal motor profile in colostomized segment[METHODS] Four force transducers (FT_<1-4>) were implanted on the colon of 9 dogs at an equidistance and another FT on the terminal ileum to distinguish the digestive from interdigestive phase. The dogs were fed either 20 or 10 g/kg meal to modify the duration of the digestive phase and a 24 recording was performed. The duration of a contraction burst (contractile state, CS) and the length of each motor quiescent state (QS) were plotted against postprandial time. Later the colon was transected between FT_2 and FT_3 to establish a double-barrelled colostomy and a 24 h recording was resumed.[RESULTS] In the intact dogs with either 20 or 10 g/kg meal, CS at each FT did not change significantly, while QS shortened at 2-4 h and began to significantly increase at 15.3(]SY.+-。[)0.3 h with 20 g/kg meal and at 11.5(]SY.+-。[)0.8 h with 10 g meal. The onset of this QS prolongation was closely correlated with the appearance of the first ileal MMC (r=0.95-0.92, p<0.001). In the colostomized dogs, the motor profile in the oral colon was identical to that before colostomy, while no prolongation of QS in the interdigestive phase occurred in the distal colon. Instead, CS and QS recurred periodically with a fixed cycle of 4.7(]SY.+-。[)0.1 min for CS and 32.6(]SY.+-。[)1.8 min for QS,respectively.[CONCLUSION] Prolongation of QS is temporally locked with the beginning of the interdigestive phase. Bowel continuity is essential for this QS prolongation to occur throughout the colon. Each segment of the colon may have its own contractile rhythm which is entrained by the rhythm in a more proximal adjacent segment (relaxation oscillator).