Intra-articular distribution of admistrated hematoporphirine in rheumatoid arthritis and selective synovialdesis using an argon-dye laser

类风湿性关节炎中血卟啉的关节内分布和使用氩染料激光的选择性滑膜固定术

• 批准号: 60570709
• 负责人: INOUE KAZUHIKO
• 金额: $ 0.83万
• 依托单位: Institute of Rheumatology, Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570709/
• 关键词: Arthroscopy; Arthroscopic surgery; Hematoporphirine; Rheumatoid arthritis; Synovectomy; アルゴン・ダイ・レーザー

(1) Intra-articular distribution of administrated hematoporphirine (HPD) was examined on 14th day after adjuvant injention to cause the adjuvant arthritis of a rat, when the maximum inflamation was found. Existence of HPD in the synovium was demonstrated by fluorescence of 680 micrometer evoked after irradiation of 2 or 3 W of argon-dye laser light. Distribution of HPD in the adjuvant arthritic synovium was found maximun 24-48 hours after HPD administration. HPD distribution in the adjuvant arthritis was found more than 10 times comparing with the normal control.(2) The human synovial tissue was obtained during arthroscopis synoventomy, and was cultured. Admistration of HPD into the culture medium, and irradiation of argon-dye laser successfully impeded or suppressed the tissue growth.(3) A patient with rheumatoid arthritis was admistrated with HPD 2 miligram/kg intravenously, and irradiated by argon-dye laser arthroscopically 48 hours after the HPD injection. Good results were obtaine … More d for 6 months, however, recurrence of the hydroarthrosis took place.(4) HPD was distributed over not only the joint synovium but whole of the body, therefore, careful protection of the skin from sun burn should be employed. This patient was secured from sun light for a week, and massive vitamine C was administrated. However, the patient still suffered from severe sun burn. The way how to protect from sun burn required furhter investigation. It was considered that intra-articular injection of HPD was superior to intravenous administration, because of more absorption into the synovial tissue and less distribution over the skin.(5) A patient with bilateral synovitis was treated with just arthroscopic synovectomy for one side, and arthroscopic synovectomy augumented with HPD injection and argon-dye laser irradiation for the other. The latter obviosly obtained better results. HPD was considered activated by agron-dye laser light and destroyed cells, however, details of the process needed further investigation. Degeneration of the synovial tissue was demonstrated after this treatment. Less

(1)用2或3 W的氩染料激光照射大鼠滑膜，观察血卟啉（HPD）在佐剂性关节炎大鼠关节内的分布，发现在佐剂性关节炎大鼠关节内的分布为14天，此时炎症最严重，用680 μ m的荧光显示HPD的存在。HPD在佐剂性关节炎滑膜中的分布在给药后24-48小时最多。佐剂性关节炎患者血卟啉衍生物的分布是正常对照组的10倍以上。(2)在关节镜滑膜切除术中获得人滑膜组织，并进行培养。将HPD加入培养液中，用氩染料激光照射，成功地阻止或抑制了组织的生长。(3)对1例类风湿关节炎患者静脉注射HPD 2 mg/kg，48 h后关节镜下用氩激光照射。取得良好效果 ...更多信息 d治疗6个月后关节积液复发。(4)HPD不仅分布于关节滑膜，而且分布于全身，因此，应小心保护皮肤免受太阳灼伤。这位病人被保护在阳光下一个星期，并给予大量的维生素C。然而，患者仍然遭受严重的晒伤。如何防止晒伤的方法需要进一步研究。关节腔内注射HPD比静脉注射更能吸收到滑膜组织中，而皮肤上的分布较少，因此认为关节腔内注射HPD比静脉注射HPD具有上级优势。(5)一例双侧滑膜炎患者，一侧仅行关节镜下滑膜切除术，另一侧在关节镜下滑膜切除术的基础上注射HPD并进行氩染料激光照射。后者显然取得了更好的效果。HPD被认为是由农业染料激光激活并破坏细胞，然而，该过程的细节需要进一步研究。治疗后证实滑膜组织变性。少

项目成果

K.Inoue,et al.: ESKA congress.

K.Inoue 等人：ESKA 大会​​。

K. Inoue, et al.: "Arthroscopic <Co_2> laser meniscectomy" Arthroscopy.

K. Inoue 等人：“关节镜 <Co_2> 激光半月板切除术” 关节镜检查。

K.Inoue,et al.: Arthroscopy.

K.Inoue 等人：关节镜检查。

K. Inoue, et al.: " <Co_2> laser meniscectomy under Arthroscopy" ESKA congress.

K. Inoue 等人：“关节镜下<Co_2>激光半月板切除术”ESKA 大会​​。

K.Inoue,et al.: Proceedings of International Society of Knee. 5. (1987)

K.Inoue 等人：国际膝关节协会论文集。