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A Trial Establish the Criteria for Evaluation of Direct Chemotherapeutic Effect in Ovarian Cancer -Forcussing on Cases with Second Look Laparotomy-

建立卵巢癌直接化疗效果评价标准的试验-以复查剖腹手术病例为探讨-

基本信息

批准号：
60570804
负责人：
NISHIMURA Haruo
金额：
$ 1.02万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570804/
关键词：
Ovarian cancer Chemotherapy History Evaluation of effect Second look operation ヌードマウス

项目摘要

1. The cases with advanced ovarian cancer who underwent exploratory laparotomy and cytoreductive surgery at initial laparotomy received chemotherapy postoperatively and also underwent second-look laparotomy in our department. These cases were entered into this retrospective study to evaluate mislleneous histopathological therapeutic effect. The histological map of the resected primary tumor was made in cases with serous cystadenocarcinoma and compared to the histological findings at second-look laparotomy. However, there was much difficulty to evaluate the histological change with chemotherapy, because of giant mass formation, degeneration, necrosis. Therefore, a correlation between the initial histological findings and clinical chemotherapeutic effect was investigated. Conclusively, the factors such as histological grading, mitotic count, and lymphatic infiltration were considered important in prognosis and in predicting chemotherapeutic effect. As a trial for evaluation of chemotherapeutic effect in cases without measurable lesion, monitering of tumor markers such as CA125, TPA, IAP was thought to be of great use in predicting histological effect of chemotherapy.2. The experimental chemotherapy against serially transplanted tumor of human muscinous cystadenocarcinoma in nude mice were done. The study showed that histological effect was well correlated to CEA value in most cases, though in some of them it was not correlated to tumor size. Thus, it was considered that reconsideration of the criteria for evaluation of direct chemotherapeutic effect postulated by JAPAN SOCIETY FOR CANCER THERAPY would be necessary. Furthermore, the experimental chemotherapy was done against the primary and the recurrent tumor xenograft in nude mice from the same patient.

1.初次开腹探查及细胞减灭术的晚期卵巢癌患者，术后接受化疗，并在我科进行二次开腹手术。这些病例纳入本回顾性研究，以评估不同的组织病理学治疗效果。在浆液性囊腺癌病例中绘制了切除的原发肿瘤的组织学图，并与第二次剖腹手术的组织学结果进行比较。然而，由于巨大肿块的形成、变性、坏死，评估化疗的组织学变化存在很大困难。因此，研究了最初的组织学结果与临床化疗效果之间的相关性。总之，组织学分级、有丝分裂计数和淋巴浸润等因素被认为对预后和预测化疗效果很重要。作为在无明显病灶的情况下评估化疗效果的试验，CA125、TPA、IAP等肿瘤标志物的监测被认为对预测化疗的组织学效果有很大作用。 2．对人粘液性囊腺癌裸鼠连续移植瘤进行了实验性化疗。研究表明，在大多数情况下，组织学效应与 CEA 值密切相关，但在某些情况下，组织学效应与肿瘤大小无关。因此，有必要重新考虑日本癌症治疗学会提出的直接化疗效果的评价标准。此外，实验性化疗是针对同一患者的裸鼠原发性和复发性肿瘤异种移植物进行的。