权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A study on the factors related with 10 year results for maxillary malignancies

上颌骨恶性肿瘤10年结果相关因素研究

基本信息

批准号：
60570813
负责人：
SAKAI Shun-ichi
金额：
$ 0.83万
依托单位：
Kagawa Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

项目摘要

Of the 1102 cases of nose- and paranasal malignancies, life condition of the long term survivors was studies. The total number of patients were 258,of which 87 cases have been observed for 5-9 years, 149 fof 10-19 years and 22 for more than 20 years.The causes of the ptients' death which occurred during the observation period were double cancer, apoplexy, decrepitude etc, As the focus of the apoplexy occurred more frequently on the side of maxillary malignancies, it could be related with the late effect of radiation therapy. The case with no symptom or with slight symptom in the performance status amounted to 80% of the subjects studied (258 cases), however, the percentages relative to the number of all registered cases (1102 cases) were 29.1% in the group of 5 years observation period, 22.9% in 10 years group and 3.4% in more than 20 years group, respectively. The results suggest the severe circumstance of this disease.The first factor limiting everyday life was the aging of the patients and the second was the radiation cataract. The cataract always occurred on the affected side, and 87.9% cases lost their sight in 10 years after the treatment. Even on the eye of the healthy side, the intact vision was found only in 65.8% of 10 years survivors.These observations showed that our recent therapy in adequate, but gave a warning in the way to select the indicating patients for the radiotherapy. It is most important to avoid the overdosis, to decide the appropriate field and protector, and to reduce the radition dose on the eye of the healthy side.As far as the totl maxillectomy is concerned, further effort must be given for deciding the cutting margin, and for improving the operation method. Cooperation with plastic surgeon is als suggested. After the operation, attention should be paid to practice the mouth opening and to treat the middle ear effusion.

本文对1102例鼻及鼻窦恶性肿瘤长期生存者的生活状况进行了研究。共观察258例，其中观察5-9年87例，10-19年149例，20年以上22例，死亡原因为双癌、中风、衰老等，因中风病灶多发生于上颌恶性肿瘤侧，可能与放射治疗的远期效应有关。体力状态中无症状或轻微症状的病例占研究对象的80%（258例），但相对于全部登记病例数（1102例）的百分比，观察期5年组为29.1%，10年组为22.9%，20年以上组为3.4%。结果提示本病病情严重，限制日常生活的首要因素是患者年龄的增长，其次是放射性白内障。白内障多发生在患侧，87.9%的患者在术后10年内丧失视力。10年生存者中，健侧视力完好者仅占65.8%，说明我们目前的治疗是充分的，但对放射治疗适应证的选择提出了警告。最重要的是避免过剂量，选择合适的术野和保护器，减少健侧眼的辐射剂量，对于全上颌骨切除术，应进一步努力确定切缘，改进手术方法。建议与整形外科医生合作。术后应注意张口训练及中耳积液的处理。