Treatment for tongue carcinoma by interstitial radiotherapy simultaneously combined with continuous chemotherapy

为提高舌癌的局部控制率，防止转移，对原发灶的舌癌采用连续注射培普霉素联合间质内放射治疗。将39例新鲜舌鳞状细胞癌患者纳入本研究，其中8例为试验组，其余为对照组。试验组在组织间放疗期间加用培普霉素10~15 mg，2~3 mg/d。放疗前加用培普霉素5 mg静滴。两组照射剂量均为60Gy48-144小时。两组治疗结束后至少3个月的局部控制率和存活率基本相同。在第一次登记时，试验组中只有1例T2是颈淋巴转移。治疗后4~6个月，共发现区域淋巴结转移3例，试验组1例，对照组2例。5例行根治性颈淋巴清扫术。所有病例均未发现远处转移。至于治疗过程中和治疗后的粘膜反应，试验组黄斑的完全消失有延迟的趋势。由于病例数量和观察期的限制，到目前为止，两组之间没有发现可再合并的差异。局部控制率和转移率的阳性结果将通过持续的长期随访来预期。

For the improvement of local control rate and the prevention of metastasis a continuous injection of Peplomycin simultaneously combined with interstitial radiotherapy was applied for the treatment of the primary lesion of tongue carcinoma. Thirty-nine fresh cases of squamous cell carcinomas of the tongue were put into this study, 8 of them were in the trial group and the others were the control. For the trial group total 10-15mg of Peplomycin were administered continuously during the period of the interstitial radiotherapy with the rate of 2-3mg per day. Prior to the inters titial radiotherapy another 5mg of Peplomycin were given intravenously. The dose of radiation was approximately 60 Gy per 48-144 hours in both groups. The local control rate and the survival rate at least 3 months after the completion of the treatment were almost the same in both groups. Only a case of T2 in the trial group was of cervical lymphnode metastasis at the first registration. The metastases to the regional lymphnode were found in total 3 cases, 1 in the trial group and 2 in the control group during 4 to 6 months after the treatment. Radical neck dissection was performed in all 5 cases. No distant metastasis was found in all cases. As to the course of mucosal reaction during and after the treatment, a complete disappearance of yellow plaque tended to delay in the trial group. Because of the limited case number and observation period there found no remerkable difference between 2 groups up to date. The positive resalts in the local control rate and the incidence of metastasis will be expected by continuing long term follow-up.