Treatment for tongue carcinoma by interstitial radiotherapy simultaneously combined with continuous chemotherapy

间质放疗联合持续化疗治疗舌癌

• 批准号: 60570925
• 负责人: FUCHIHATA Hajime
• 金额: $ 0.96万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570925/
• 关键词: Tongue carcinoma; Interstitial radiotherapy; Continuous chemotherapy; 同時併用

For the improvement of local control rate and the prevention of metastasis a continuous injection of Peplomycin simultaneously combined with interstitial radiotherapy was applied for the treatment of the primary lesion of tongue carcinoma. Thirty-nine fresh cases of squamous cell carcinomas of the tongue were put into this study, 8 of them were in the trial group and the others were the control. For the trial group total 10-15mg of Peplomycin were administered continuously during the period of the interstitial radiotherapy with the rate of 2-3mg per day. Prior to the inters titial radiotherapy another 5mg of Peplomycin were given intravenously. The dose of radiation was approximately 60 Gy per 48-144 hours in both groups. The local control rate and the survival rate at least 3 months after the completion of the treatment were almost the same in both groups. Only a case of T2 in the trial group was of cervical lymphnode metastasis at the first registration. The metastases to the regional lymphnode were found in total 3 cases, 1 in the trial group and 2 in the control group during 4 to 6 months after the treatment. Radical neck dissection was performed in all 5 cases. No distant metastasis was found in all cases. As to the course of mucosal reaction during and after the treatment, a complete disappearance of yellow plaque tended to delay in the trial group. Because of the limited case number and observation period there found no remerkable difference between 2 groups up to date. The positive resalts in the local control rate and the incidence of metastasis will be expected by continuing long term follow-up.

为提高局部控制率，预防转移，对舌癌原发灶采用持续注射培普霉素联合间质放疗的方法。本研究纳入39例新鲜舌鳞状细胞癌病例，其中8例为试验组，其余为对照组。对于试验组，在间质放射治疗期间连续施用总共10-15mg的佩普霉素，每天2-3mg。在间质放射治疗之前，静脉注射另外 5mg 的佩普霉素。两组的辐射剂量约为每 48-144 小时 60 Gy。两组的局部控制率和治疗完成后至少3个月的生存率几乎相同。试验组中仅有1例T2病例在首次登记时出现颈部淋巴结转移。治疗后4～6个月内发现区域淋巴结转移共3例，试验组1例，对照组2例。 5例均行根治性颈清扫术。所有病例均未发现远处转移。至于治疗期间和治疗后的粘膜反应进程，试验组的黄色斑块完全消失有延迟的趋势。由于病例数和观察期有限，迄今为止未发现两组之间存在显着差异。通过持续的长期随访，预计局部控制率和转移发生率将取得积极结果。