Design of New Condensation System by the Facilitated Permeation through the Porous Block Copolymer Membrane

多孔嵌段共聚物膜促进渗透新型冷凝系统的设计

• 批准号: 61550675
• 负责人: HASHIMOTO Kazuhiko
• 金额: $ 1.22万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61550675/
• 关键词: Consdensation; Protein; Facilitated Permeation; Porous Membrane; Polyamide; Polyoxyethylene; ポリオキシエチレン; 吸着; ブロック共重合体

A new ABA-type block copolymer (1) composed of polyamide (2) as outer segments and polyoxyethylene as an inner segment was prepared by the anionic polymerization of a bicyclic oxalactam 3. A polyoxyethylene having terminal isocyanate groups (4) was used as an activator obtained from polyoxyethylene glycol and an excess of tolylene-2,4-diisocyanate. A porous membrane was prepared by casting the solution of the mixture of 1 with polyoxyethylene glycol and drying up at room temperature, followed by immersing and rinsing in water. In the solute rejection test for myoglobin, the concentration of the permeate was found to be much higher than that in the feed. Such peculiar condensation was much dependent not only upon the casting conditions for the porous membrane, but also upon permeation conditions such as the pressure difference, mechanical stirring, the initial concentration of protein solutions, and the addition of electolyte. The present transport system is presumed to result from the delicate combination of the rapid adsorption of proteins onto the porous membrane and their transport driven by the lower pressure.

通过双环内酰胺3的阴离子聚合，制备了一种由聚酰胺（2）作为外链段和聚氧乙烯作为内链段组成的新型ABA型嵌段共聚物（1）。具有末端异氰酸酯基的聚氧乙烯（4）用作活化剂，该活化剂由聚氧乙烯二醇和过量的甲苯-2，4-二异氰酸酯获得。通过将1与聚氧乙烯乙二醇的混合物的溶液浇铸并在室温下干燥，随后在水中浸泡和冲洗来制备多孔膜。在肌红蛋白的溶质截留试验中，发现渗透物的浓度远高于进料中的浓度。这种特殊的凝聚不仅取决于多孔膜的浇铸条件，而且还取决于渗透条件，如压力差、机械搅拌、蛋白质溶液的初始浓度和电解质的添加。目前的运输系统被认为是由蛋白质的快速吸附到多孔膜上和它们的运输由较低的压力驱动的微妙的组合。

项目成果

橋本和彦: Polymer Journal. 19. 1139-1145 (1987)

桥本和彦：聚合物杂志 19. 1139-1145 (1987)

橋本和彦: Polymer Journal.

桥本和彦：聚合物杂志。

Hashimoto, Kazuhiko: "Novel Condensation System for Aqueous Solutions of Proteins. Facilitated Permeation of Proteins through the Porous Membrane Prepared from the Block Copolymer Consisting of Hydrophilic Polyamide and Polyoxyethylene Segments" Polymer J

Hashimoto, Kazuhiko：“蛋白质水溶液的新型缩合系统。促进蛋白质通过由亲水性聚酰胺和聚氧乙烯片段组成的嵌段共聚物制备的多孔膜渗透”聚合物 J

Hashimoto, Kazuhiko: "Hydraulic Permeability-Temperature Hysteresis for the Hydrophilic Membrane Prepared from the Block Copolymer Consisting of Polyamide and Polyoxyethylene Segments" Polymer Journal. 19. 249-256 (1987)

Hashimoto、Kazuhiko：“由聚酰胺和聚氧乙烯链段组成的嵌段共聚物制备的亲水膜的水力渗透率-温度滞后”聚合物杂志。

橋本和彦: Polymer Journal. 【19!_】. 249-256 (1987)

桥本和彦：聚合物杂志[19！_]。