Studies on the host resistance to infection with larval cyclophyllidean cestodes

寄主对环叶绦虫幼虫感染的抵抗力研究

• 批准号: 61560331
• 负责人: OKU Yuzaburo
• 金额: $ 0.96万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61560331/
• 关键词: Life cycle; Innate resistance; Echinococcus multilocularis; Taenia hydatigena; Taenia taeniaeformis; Taenia hydatigena; Taenia crassiceps; 肥満細胞; 円葉条虫

1. Infectivity of three isolates of Taenia taeniaeformis (Hokkaido-Rattus, Malaysia-Rattus and Hokkaido-Clethrionomys isolates) varied in some wild and experimental rodents, especially rat and Clethrionomys rufocanus. 2. The rodents, which were resistant to oral infection with eggs of Taenia hydatigena, were susceptible to intraperitoneal inoculation of immature cysticercus. 3. Significant difference was observed in susceptibility of some experimental animals and C. rufocanus to oral infection of eggs or to intraperitoneal inoculation of larvae of Echinococcus multilocularis and Taenia crassiceps. 4. In cortisone-treated, X-ray-irradiated and cyclophosphamide-treated mice, the larvae of T. taeniaeformis survived for longer period than that in cobra venom factor-treated, carrageenan-treated and control mice. 5. Egg of E. multilocularis is very danger to breeders, so dogs were operated surgically, so a separated small intestine were produced in the perotoneal cavity of the dog. In the separated small intestine, the injected protoscolices of E. multilocularis did not developed, and were dead in short period. 6. Gorden hamsters were infected orally with larvae of E. multilocularis and T. crassiceps. In the small intestine of the host, E. multilocularis were developed, and mature segument were observed. T. crassiceps produced eggs in hamsters. 7. Experiments using inbred mouse and in vitro experiments are carrying out.

1. 3个带绦虫（Hokkaido-Rattus、Malaysia-Rattus和Hokkaido-Clethrionomys）分离株在部分野生和实验啮齿类动物中，特别是在大鼠和红腹竹鼠中的繁殖力存在差异。2.对经口感染包虫虫卵有抵抗力的鼠类，对腹腔接种未成熟囊尾蚴敏感。3.部分实验动物和C.红口绦虫对经口感染虫卵或腹腔接种多房棘球绦虫和粗头绦虫幼虫的影响。4.在可的松处理、X射线照射和环磷酰胺处理的小鼠中，T。带形绦虫的存活时间长于眼镜蛇毒因子处理的、角叉菜胶处理的和对照小鼠。5.鸡蛋E。由于多房性肠梗阻对饲养员的危害很大，因此对狗进行了手术，在狗的腹膜腔中产生了一个分离的小肠。在离体小肠中，注射E.多房虫不发育，短期内死亡。6.戈登仓鼠经口感染E. multilocularis和T.粗头鱼在宿主的小肠中，E.多室层发育，成熟分节段发育。T.在仓鼠体内产卵。7.利用近交系小鼠进行实验和体外实验。

项目成果

宮地俊: 寄生虫学雑誌. 36(1.補). 43 (1987)

宫地舜：《寄生虫学杂志》36（1.补充）43（1987）。

野中成晃: 寄生虫学雑誌. 36(1.補). 43-44 (1987)

N. Nonaka：《寄生虫学杂志》36（1.补充）43-44（1987）。