Environmental adaptation of Taeniods in Latin America

拉丁美洲带虫的环境适应

• 批准号: 09041137
• 负责人: OKU Yuzaburo
• 金额: $ 7.49万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09041137/
• 关键词: Echinococcus granulosus; Coproantigen; Environment adaptation; Epidemiology; Latin Americ; Uruguay; E. vogeli; Parasite; アルゼンチン; 有鉤条虫; ホンジュラス; ブラジル

Parasites adapt to their environment, and become steady in endemic area. Echinococcus granulosus are distributed in world wide, especially sheep breeding countries, and important zoonosis in such countries. Taenia solium is also zoonosis, and cause the cerebral cysticercosis in Latin America. Intraspecific variations are prominent in E. granulosus in the world, there are many variations are reported. Epidemiologicalstatus and environmental adaptation of Echinococcus granulosus, E, vogeli and Taenia solium in Latin America were studied. We carried out a survey of Taenia solium in pigs of Honduras and Brazil, but very difficult to find positive cases in Brazil. Most important industry of Uruguay is livestock industry. Prevalence of E. granulosus in sheep was determined in 1991 and 1999. In Uruguay, Control measure against E. granulosus was changed in 1991-2. The prevalence in sheep had been drastically reduced in 1998-9. It is very difficult to find infected dogs in 1998. So, we tried to produce monoclonal antibodies for developing a new high sensitive immunodiagnostic method for dogs using monoclonal antibodies. A monoclonal antibody was useful for Echinococcus multilocularis. Intraspecific variations of E. granulosus in Uruguay were not shown in our samples from sheep. We tried to establish alternative definitive hosts of E. granulosus and E. vogeli, and succeed only for E. vogeli using Mongolian jirds treated with predonisolone. The development in the small intestine were observed in jirds.

寄生虫适应环境，在流行地区变得稳定。细粒棘球绦虫分布在世界各地，特别是绵羊养殖国家，是这些国家重要的人畜共患病。猪带绦虫也是一种人畜共患病，在拉丁美洲引起脑囊虫病。在世界范围内，颗粒棘球绦虫的种内变异很突出，有许多变异的报道。研究了拉丁美洲细粒棘球绦虫、伊氏棘球绦虫、沃格里棘球绦虫和猪带绦虫的流行病学现状及环境适应性。我们在洪都拉斯和巴西的猪中开展了猪带绦虫调查，但在巴西很难发现阳性病例。乌拉圭最重要的产业是畜牧业。1991年和1999年测定了绵羊中颗粒棘球绦虫的流行情况。乌拉圭在1991- 1992年改变了对细粒绦虫的控制措施。1998- 1999年，绵羊中的流行率急剧下降。在1998年很难找到受感染的狗。因此，我们尝试制备单克隆抗体，利用单克隆抗体开发一种新的高灵敏度犬类免疫诊断方法。单克隆抗体对多房棘球绦虫有效。乌拉圭细粒棘球绦虫的种内变异未在我们的绵羊样本中显示出来。我们尝试建立颗粒棘球绦虫和沃格里棘球绦虫的替代最终宿主，并且仅用强的松龙处理过的蒙古鸟对沃格里棘球绦虫有效。在鸟类中观察到小肠的发育。

项目成果

NONAKA N.: "Monitoring of Echinococcus multilocularis infection in red foxes in Shiretoko, Japan, by coproantigen detection"Parasitology. 117(2). 193-200 (1998)

NONAKA N.：“通过粪抗原检测来监测日本知床红狐的多房棘球绦虫感染”寄生虫学。

KONNO K.: "Histopathology and physiopathology of gastric mucouse hyperplasia in rats heavily infected with Taenia taeniaeformis"Journal of Veterinary Medical Science. 61(4). 317-324 (1999)

KONNO K.：“严重感染绦虫带状绦虫的大鼠胃粘膜增生的组织病理学和生理病理学”兽医医学杂志。

Sakai, H.: "Coproantigen detection in a survey of Echinococcus multilocularis infection among red foxes, Vulpes vulpes schrencki, in Hokkaido, Japan."Journal of Veterinary Medical Science. 60(5). 639-641 (1998)

Sakai, H.：“日本北海道赤狐 (Vulpes vulpes schrencki) 多房棘球绦虫感染调查中的粪抗原检测。”兽医医学杂志。

SAKAI H.: "Coproantigen detection in a routine fox survey of Echinococcu multilocularis infection in Hokkaido, Japan"Parasitology International. 47(1). 47-51 (1998)

SAKAI H.：“日本北海道多房棘球绦虫感染例行狐狸调查中的粪抗原检测”国际寄生虫学。

SAKAI H.: "Coproantigen detection in a survey of Echinococcus multilocularis infection among red foxes, Vulpes schrencki, in Hokkaido, Japan"Journal of Veterinary Medical Science. 60(5). 639-641 (1998)

SAKAI H.：“日本北海道赤狐（Vulpes schrencki）多房棘球绦虫感染调查中的粪抗原检测”兽医医学杂志。