Studies on Pathogenesis of Nephritis on Domestic Animals

家畜肾炎发病机制的研究

• 批准号: 61560336
• 负责人: TAKAHASHI Reiji
• 金额: $ 1.09万
• 依托单位: Azabu University (1987-1988)The University of Tokyo (1986)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61560336/
• 关键词: Animals; Dod; Cat; Canine filariasis; FIP; 腎炎; フィラリヤ; 発生率

Pathogenesis of interstitial nephritis in dogs and cats were studied pathologically and immunopathologically.The results were as follows ;(a) Eighty-six cases of dogs necropsied were examined histopathologically, special reference with nephritis. The occurrence rate of dogs with interstitial nephritis raised accompanied by advance in age. The glomerular changes were also found more than interstitial nephritis in number, especially in younger group, and all but one kidney with inflammatory changes showed both glomerular and interstitial nepharitis. Then, it was considered that the glomerular changes were induced in young by some agents , which might cause chronic or subclinical infections, and followed by interstitial nephritis.(b) Based on the speculation that the Dirofilaria immitis (f) might be one of the most possible agent cause canine glomerular changes, the renal changes on dogs with F in the heart were examined. Conclusively,the specific renal changes in the dogs with filariasis were membranous glomerular nephritis associated with hemosiderosis in tubular epithelial cells and interstitial nephritis. And, it was suggested that the glomerular changes must be caused by immunological mechanism.(c) To confirm the immunological mechanism was induced by F antigen,fluorescent antibody was used, but it had not bend detected. And also the glomerular changes associated with FIP were suggested to be immune complex-mediated lesions, then, electron microscopic study was performed, but no virus particles were detected.

本文从病理学和免疫病理学两方面研究了犬、猫间质性肾炎的发病机理，结果如下：（1）对86例犬尸检标本进行了组织病理学检查，特别是肾炎。间质性肾炎的发生率随年龄的增长而增加。肾小球病变的数量也多于间质性肾炎，尤其是在年轻组中，除1例有炎性改变外，所有肾脏均表现为肾小球和间质性肾炎。因此，认为某些药物在青年时引起肾小球改变，可能引起慢性或亚临床感染，继而发生间质性肾炎。(b)基于犬心丝虫（Dirofilaria immitis，f）可能是引起犬肾小球病变最可能的病原体之一的推测，我们观察了心丝虫病犬肾脏的病变。结论：丝虫病犬肾脏的特异性改变是膜性肾小球肾炎伴肾小管上皮细胞含铁血黄素沉着和间质性肾炎。提示肾小球病变可能是由免疫机制引起的。(c)为证实F抗原诱导的免疫机制，用荧光抗体检测，未检测到弯曲。FIP引起的肾小球病变可能是免疫复合物介导的病变，电镜观察未见病毒颗粒。