A Retrospective Cohort Study of the Histologically Confirmed Chronic Liver Diseases

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In order to caluculate the survival rate of chronic liver diseases and to elucidate the risk factors of liver cancer, 1,034 patients of the chronic liver diseases were followed up. All patients were confirmed histologically from 1973 to 1982 in juntendo University hospital. Suspended personal risk factors. such as alcohol intake, cigarrette smoking, HBV markers and so on were obtained from hospital records. Untill the end of 1986, all cases were mainly followed by koseki system. The mean follow-up period was 7.1 and 244 cases were died including 52 cases of liver cancer. The number of liver cancer death was 34(or 12.7%) of male liver cirrhosis, 5(or 5.0%) of female liver cirrhosis, 11(or,2.3%) of male chronic hepatitis and 1(or 0.6%) of temale chronic hepatitis, respectively.The 10 years survival rate by Kaplan-Meyer's method ranged from 39.85 for male liver cirrhosis to 80.64 for male chronic hepatitis. The results of proportional hazard mofel for male liver cirrhosis revealed that drinking alcohol affected negatively to the liver cancer, and that cigarrette smoking and no history of operation due to portal hypertension affected to it and that age at biopsy HBS antigen, history of blood transfusion and history of acute hepatitis almost have no relation to it.