Relationship between life-style and cause of death in Higashi-Yamanashi cohort

东山梨队列中生活方式与死因的关系

• 批准号: 11670351
• 负责人: INABA Yutaka
• 金额: $ 1.79万
• 依托单位: JUNTENDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670351/
• 关键词: Cohort study; Life style; cancer; Heart disease; Cerebro-vasculer diseases; 比例ハザードモデル; 食生活

Background : In the three municipalities of Higashi-Yamanashi County, Japan, we conducted a cohort study since 1989.Participants of this study were about 9,000 persons aged over 30 years. We conducted a survey using self-administered questionnaires consisted of about 200 items of baseline life-style on 1989.Purpose : The aim of this study was to evaluate the effect of life-style related risk factors, especially food intake, for mortality of cerebral infarction, stomach cancer, and lung cancer in the Higashi-Yamanashi cohort in Japan. Methods : Vital statistics and death certificates were obtained from 1989 to 1999 and linked with the base-line data. Results : Table. 1 Number of survival, death and move out cases(1989〜1999) Male(%) FeMale(%) Survive 3438(80.2) 4111(86.0) Death 676(15.8) 464(9.7) Move out 175(4.1) 204(4.3) Total 4289(100.0) 4779(100.0) Table. 2 Causes of death Cause of death Number(%) Malignant neoplasms 374(33.2) Stomach cancer 91(8.0) Lung cancer 64(5.6) Heart diseases … More 202(17.7) Cerebrovascular diseases 149(13.1) Cerebral Infarction 93(8.2) Others 415(36.4) Total 1140(100.0) Table. 3 Hazard risk ratio of several risk factors Cerebral infarction-Male Hazard Ratio(95%CI) Alcohol drinking(ex/non) 2.3(1.1-1.5) Sleeping hours per day(9+/7-8) 2.0(1.1-3.8) Cheese intake (1-2per m/non) 0.3(0.3-0.9) Japanese cake(1-2 per m/non) 0.1(0.0-0.7) Cerebral infarction-Female Hazard Ratio(95%CI) Exercise per week(1h+/non) 2.0(1.0-4.3) Pickles intake(everyday/non) 0.3(0.1-0.9) Stomach Cancer-Male Hazard Ratio(95%CI) Fish intake per week(3-4/<1-2) 2.8(1.1-7.3) Exercise per week(5h+/non) 2.4(1.1-5.3) Walking time per day(0.5h+/non) 0.4(0.2-0.8) Green vegetable intake(1+ per M/non) 0.2(0.1-0.95) Stomach Cancer - Female Hazard Ratio(95%CI) Tomato intake(1-2 per w/non)0.2(0.1-0.8) Lung Cancer(Male) Hazard Ratio(95%CI) Seaweed intake(everyday/non) 0.3(0.1-0.9) Conclusions : Green vegetable intake and walking may be preventive factors for stomach cancer. However, further analysis will be necessary. Less

背景资料：从1989年开始，我们在日本东山梨县的三个市进行了一项队列研究，研究对象为约9，000名30岁以上的人。我们于1989年进行了一项由大约200项基线生活方式组成的自填问卷调查。目的：本研究的目的是评估日本东山梨队列中与生活方式相关的危险因素，特别是食物摄入对脑梗死、胃癌和肺癌死亡率的影响。方法：获得1989年至1999年的生命统计数据和死亡证明，并与基线数据相关联。结果：表。1存活、死亡及迁出个案数目（1989至1999年）男性（%）女性男性（%）存活3438（80.2）4111（86.0）死亡676（15.8）464（9.7）迁出175（4.1）204（4.3）合计4289（100.0）4779（100.0）表2死亡原因死亡原因人数（%）恶性肿瘤374（33.2）胃癌91（8.0）肺癌64（5.6）心脏病 ...更多信息 202（17.7）脑血管疾病149（13.1）脑梗塞93（8.2）其他415（36.4）合计1140（100.0）表. 3几种危险因素的危险风险比脑梗死-男性危险比（95%CI）饮酒（有/无）2.3（1.1-1.5）每天睡眠时间（9+/7-8）2.0（1.1-3.8）奶酪摄入量（1- 2每米/非）0.3（0.3-0.9）日式蛋糕（1-2每米/非）0.1（0.0-0.7）脑梗死-女性风险比（95%CI）每周运动（1h+/非）2.0（1.0-4.3）泡菜摄入量（每日/非）0.3（0.1-0.9）胃癌-男性风险比（95%CI）每周鱼类摄入量（3-4/<1-2）2.8（1.1-7.3）每周运动（5小时+/非）2.4（1.1-5.3）每天步行时间（0.5小时+/无）0.4（0.2-0.8）绿色蔬菜摄入量（1+/男/非）0.2（0.1-0.95）胃癌-女性风险比（95%CI）番茄摄入量（1-2/w/non）0.2（0.1-0.8）肺癌（男性）风险比（95%CI）海藻摄入（每天/非）0.3（0.1-0.9）结论：绿色蔬菜摄入和散步可能是胃癌的预防因素。然而，还需要进一步分析。少