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Degeneration of Machine oils and the generation of toxicity during Their Recycled use- Studies from the view point of industrial health.

机械油的变质及其回收使用过程中毒性的产生 - 从工业健康角度进行的研究。

基本信息

批准号：
61570274
负责人：
KIRA Shohei
金额：
$ 1.28万
依托单位：
Okayama University Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

Machine oils are widely used in metal processing factories and a water soluble or emulsifiable type has become predominant in the work place. During their recycled use process, a high temperature and a high pressure on the metal surface could play a role in generating new toxic substances unpredicted before use. The present studies concern the detection of mutagenicity and its monitoring in cutting fluids with the lapse of time of recycled use, and the measurement of oil mists in the work places.1. After the blue cotton extraction, one of 11 unused water soluble cutting fluids tested here showed mutagenic activity detected by the Ames test with Salmonella TA98 without metabolic activation. 2. With the Sep-Pak C18 extraction, polar fractions of an unused and a recycle-used water soluble cutting fluids showed mutagenicity by TA100 without metabolic activation. 3. Some machine oils being collected as the lapse of time showed mutagenicity after 60-90 days of use. 4. As a portable sampler for oil mists, we tested a head of the TR sampler with two stages built in, and collected the oil mists on stainles-steel plate. We also tested an oil meter for the measurement of oil components collected on the plate after extraction with CC14. The results were well corresponded to those with the low volume sampler, which collects the oil mists in a glass fiber filter and is a conventional method.The above results suggested that monitorings of both the levels of oils in the ambient air and the toxicities such as mutagenicity in the fluid, could work for the protection of health of worker in machine work shops, through an environmental control system.

机械油广泛用于金属加工厂，水溶性或可溶解型机械油已成为工作场所的主要润滑油。在其回收利用过程中，金属表面的高温和高压可能会产生使用前无法预测的新有毒物质。目前的研究涉及的诱变性的检测和监测切削液随着时间的推移，回收使用，并在工作场所的油雾测量。在蓝色棉浸提后，在此测试的11种未使用的水溶性切削液中，有一种通过使用沙门氏菌TA 98（不含代谢活化）进行的艾姆斯试验检测到致突变活性。2.使用Sep-Pak C18浸提，未使用和已使用的水溶性切削液的极性组分在无代谢活化的情况下通过TA 100显示出致突变性。3.随着时间的推移，收集的一些机油在使用60-90天后显示出致突变性。4.作为一种便携式油雾采样器，我们测试了一个TR采样器的头部，内置两个阶段，并收集油雾在不锈钢板。我们还测试了油量计，用于测量用CC 14萃取后收集在板上的油组分。结果表明，通过环境控制系统监测环境空气中的油含量和油液中的致突变性等毒性物质，可以起到保护工人健康的作用。