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Serum lipids in hypertensive twins

高血压双胞胎的血脂

基本信息

批准号：
61570281
负责人：
SHIMIZU Tadahiko
金额：
$ 1.22万
依托单位：
Kinki University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570281/
关键词：
双生児血清脂質高血圧

项目摘要

A gemellological study was conducted on serum concentrations of lipids and electrolytes,blood pressure,and obesity to estimate the relateve strength of genetic and environmental influences. The subjects were 107 pairs of ajult twins (81 monozygotic pairs,26 dizygotic pairs),who were residing in the community and aged over 50. The items examined in this study were total cholesterol,HDL cholesterol,LDL cholesterol, triglyceride, -lipoprotein,phospholipid,free fatty acid,apolipoproteins(A-I,A-II,B,C-II,C-III,E),thrombocyte, uric acid,Na,K,Ca,blood pressure,skinfold thickness,body weight and body hei-ght. The heritability was estimated from the data of of male twins through variance analysis. Environmental variance was statistically adjusted between monozygotic and dizygotic twins through nulti-regression analysis.1. Regarding to the serum lipids, strong heritability was shown in HDL cholesterol (0.667),apo B (0.667), LDL cholesterol (0.608). On the other hand,triglyceride, apo A-II and apo C-III showed a low level of heritability (0.2 and less).2. Serum electrolytes (Na,K,Ca) and uric acid showed a low level of heritability (under 0.3).3.Blood pressure showed a relatively high level of heritability (systoric:0.549,diastric:0.598).4. Strong influences of environmental factors were shown in skinfold thickness.

对血脂和电解质、血压和肥胖的血清浓度进行了一项生殖细胞学研究，以估计遗传和环境影响的相对强度。研究对象为107对年龄在50岁以上的双胞胎（81对为单卵双胞胎，26对为双卵双胞胎）。本研究检测的项目有总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、β-脂蛋白、磷脂、游离脂肪酸、载脂蛋白（A-I、A-II、B、C-II、C-III、E）、血小板、尿酸、钠、钾、钙、血压、皮褶厚度、体重和身高。根据男性双生子的资料，通过方差分析估计遗传力.通过多元回归分析，对单卵双生子和双卵双生子之间的环境变量进行了统计学调整.在血脂方面，高密度脂蛋白胆固醇（0.667）、载脂蛋白B（0.667）、低密度脂蛋白胆固醇（0.608）具有较强的遗传力。另一方面，甘油三酯、载脂蛋白A-II和载脂蛋白C-III显示出低水平的遗传力（0.2或更低）。血清电解质（Na、K、Ca）和尿酸的遗传度较低（均在0.3以下）; 3.血压的遗传度较高（收缩压：0.549，舒张压：0.598）.皮褶厚度受环境因素影响较大。