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Research of the oxygen and glucose metabolism and their relationship in hepatic tumors with positron emission computed tomography

正电子发射计算机断层扫描研究肝肿瘤氧糖代谢及其关系

基本信息

批准号：
17591430
负责人：
TANIGUCHI Hiroki
金额：
$ 2.32万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Malignant tumors repeat cell division and also proliferation actively even in bad environment. Consequently, it is thought that the glycolytic pathway largely contributes to getting energy for cell proliferation. In other words, anaerobic glucose metabolism is greatly facilitated not in normal tissue but in malignant tumor. Examination with positron emission computed tomography (PEI) using 18F-fluorodeoxygluoose (FDG) is to apply this phenomenon. Even though differential diagnosis which the tumor is benign or malignant and definition of invasive area are difficult, FDG-PET makes qualitative diagnosis possible by imaging study. On the other hand, FDG-PET enable quantitative evaluation of tumor glucose metabolism Detection rate by FDG-PET is extremely low in hepatocellular carcinoma (HCC), although it in malignant tumor is high even in metastatic liver tumor. It is thought that fundamental differences between (HCC) and the other cancer are due to their blood supply. HCC is rich in the bl … More ood vessels than the other cancer and it blood supply is abundant. In other words, it is thought that glucose metabolism is active in HCC. FDG-PET is indicator of anaerobic glucose metabolism and negative image of FDG-PET indicate to aerobic metabolism. Namely, it is expected that there is inverse correlation between blood flow in the cancer and anaerobic glucose metabolic rate (detection rate of FDG-PEI).The purpose of this research is to clarify the reason of low detection rate of HCC in FDG-PET.The relationship between the blood supply and anaerobic glucose metabolism of the tumor seem to be universal exceeding the kind of neoplasm. As results, anaerobic glucose metabolism related to blood flow and oxygen consumption in HCC, and also it related to oxygen consumption rate in other malignant tumors. It was thought that xygen deficiency is supplemented with elevation of effective oxygen consumption (oxygen consumption rate) in malignant tumors, but oxygen deficiency is supplemented with increase in blood flow in HCC. Less

恶性肿瘤在恶劣的环境中也会积极地重复细胞分裂和增殖。因此，认为糖酵解途径在很大程度上有助于获得细胞增殖所需的能量。换句话说，无氧葡萄糖代谢在正常组织中而在恶性肿瘤中大大促进。使用18F-氟脱氧葡萄糖（FDG）的正电子发射计算机断层扫描（PEI）检查就是应用这种现象。尽管肿瘤的良恶性鉴别诊断和浸润范围的确定很困难，但FDG-PET通过影像学研究使定性诊断成为可能。另一方面，FDG-PET可以定量评估肿瘤葡萄糖代谢。FDG-PET在肝细胞癌（HCC）中的检测率极低，但在恶性肿瘤中甚至在转移性肝脏肿瘤中的检测率也很高。据认为，肝细胞癌（HCC）和其他癌症之间的根本区别是由于它们的血液供应。肝癌富含胆汁， ...更多信息血管比其他癌症好，血液供应丰富。换句话说，认为葡萄糖代谢在HCC中是活跃的。FDG-PET是无氧葡萄糖代谢的指标，FDG-PET的负像指示有氧代谢。本研究的目的是阐明肝癌FDG-PET检出率低的原因，肿瘤的血供与无氧葡萄糖代谢的关系似乎比肿瘤的种类更具有普遍性。结果表明，无氧葡萄糖代谢与肝细胞癌的血流量和耗氧量有关，也与其他恶性肿瘤的耗氧率有关。以往认为，在恶性肿瘤中，氧缺乏伴随着有效氧消耗（氧消耗率）的提高而得到补充，但在HCC中，氧缺乏伴随着血流量的增加而得到补充。少