Allergological studies on bronchial asthma due to insects. -- The demonstration of the high frequencies of moth, butterfly, caddis fly, and chironomid allergies and their airborne particles smaller than 10 m in diameter.

在认识到天蛾、蝴蝶、石蛾和摇蚊是在我们的环境中主要发现的昆虫之后，用蚕蛾和/或蝴蝶过敏的检测、石蛾对石蛾过敏的检测和摇蚊对摇蚊过敏的检测以及摇蚊全身对摇蚊过敏的检测来研究哮喘患者对这些昆虫的反应性敏感性。随机选择的56名哮喘患者中至少有50%对这些昆虫提取物有皮内反应阳性，至少有80%的皮肤反应阳性患者有特异性IgE抗体。一个在春天（蚕蛾翅3.18ng/m3，石蛾翅3.08ng/m3，摇蚊全身5.21ng/m3）和秋季各1只蚕翅为8.24ng/m^3，石蛾翅为4.74ng/m^3，摇蚊全身18.19ng/m^3），虽然我们不知道这样的峰值是否足以引起哮喘症状，用该方法测得的昆虫特异性IgE抗体的季节性波动与大气昆虫变应原的季节性波动相似，表明昆虫是一种广泛存在的常见吸入性变应原。

After recognizing tnat moth, butterfly, caddis fly, and chironomid were the insects predominantly found in our environment, reaginic sensitivities to these insects in patients with asthma were investigated with extracts of silkworm wing for the detection of moth and/or butterfly allergy, caddis fly wing for caddis fly allergy, and chironomid whole body for chironomid allergy. At least 50% of 56 randomly selected patients with asthma had positive intracutaneous reactions to these insect extracts, and at least 80% of the skin reaction positive patients had specific IgE antibodies.An immunochemical assay of these insect-related aeroallergens in the dust collected 18.6m above ground revealed the presence in the air of insect-related particles smaller than 10 m in diameter with two peaks a year, one in the spring(silkworm wing, 3.18ng protein equivalent to that of the crude extract per cubic meter of air; caddis fly wing, 3.08ng/m^3, and chironomid whole body, 5.21ng/m^3) and one in the autumn(silkworm wing, 8.24ng/m^3; caddis fly wing, 4.74ng/m^3; and chironomid whole body, 18.19ng/m^3).Although we have no idea whether or not such peak values are enough to cause asthmatic symptoms, seasonal fluctuations of specific IgE antibodies to these insects appeared to be similar to those of atmospheric insect allergens measured by this method.These findings suggest that insects are widespread and common inhalant allergens.