Relationship between Coronary Circulation and Myocardial Function in the Right Heart

右心冠脉循环与心肌功能的关系

• 批准号: 61570423
• 负责人: KOYANAGI Samon
• 金额: $ 1.28万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570423/
• 关键词: Myocardial Function; Coronary Circulation; Coronary Autoregulation; 右室肥大; 右室機能; 局所心筋機能; 心筋血流量; 心筋梗塞サイズ

The relationship between coronary perfusion pressure and regional myocardial performance of the right ventricular free wall was studied,in the presence or absence of right ventricular hypertemsion in 13 open-chest dogs.The right coronary artery was perfused through a shunt from a carotid artery.Regional systolic shortening of the right ventricular free wall was measured by means of a sonomicrometric technique at various levels of coronary perfusion pressure.Regional shortening was insensitive to coronary perfusion pressure or flow when it was above 31 mm Hg or 0.27 ml/min per g.Once coronary perfusion was below this critical level, regional shortening in both base to apex and circumferential orientations decreased linearly, depending on the degree of perfusion pressure. Despite the presence of a monoexponential relationship between coronary perfusion pressure or flow and regional shortening, a direct linear relation between perfusion pressure and flow was consistently noted,with or without pulmonary artery banding,suggesting that there is limited autoregulation of right coronary flow.The critical perfusion pressure for maintaining regional myocardial function of the right ventricle was highly dependent on the level of right ventricular systolic pressure (r=0.64-0.72,P<0.05).Thus,right ventricular systolic pressure was one of the important determinants of regional wall motion during coronary underperfusion.

本文研究了13只开胸犬在存在或不存在右室高血压的情况下，冠状动脉灌注压与右心室游离壁局部心肌表现的关系。右冠状动脉通过颈动脉分流进行灌注。在不同水平的冠状动脉灌注压力下，通过声速测量技术测量了右心室游离壁的局部收缩缩短。当冠脉灌注压力或血流高于31 mm Hg或0.27 ml/min / g时，局部缩短对冠脉灌注压力或血流不敏感。一旦冠脉灌注低于此临界水平，根据灌注压力的程度，基底至顶点和周向的区域缩短均呈线性下降。尽管冠状动脉灌注压力或血流与区域缩短之间存在单指数关系，但灌注压力和血流之间始终存在直接的线性关系，无论有无肺动脉带，这表明右冠状动脉血流存在有限的自动调节。维持右心室局部心肌功能的临界灌注压高度依赖于右心室收缩压水平（r=0.64 ~ 0.72，P<0.05）。因此，右心室收缩压是冠状动脉灌注不足时局部壁运动的重要决定因素之一。

项目成果

小柳左門,中村元臣: Geriatric Medicine. 24. 1586-1590 (1986)

Samon Koyanagi，Motoomi Nakamura：老年医学。24. 1586-1590 (1986)

Urabe Y.;Tomoike H.;Ohzono K.;Koyanagi S.;Nakamura M.: Circulation Research. 57. 96-104 (1985)

Urabe Y.；Tomoike H.；Ohzono K.；Koyanagi S.；Nakamura M.：循环研究。

小柳左門,中村元臣: 内科. 59. 9-14 (1987)

Samon Koyanagi，Motoomi Nakamura：内科医学。 59. 9-14 (1987)

Ohzono K.;Koyanagi S;Urabe Y.;Tomoike H.;Nakamura M.: Circulation Research. 59. 63-73 (1986)

Ohzono K.；Koyanagi S；Urabe Y.；Tomoike H.；Nakamura M.：循环研究。

Koyanagi S.;Nabeyama S.;Ohzono K.;Takeshita A.;Nakamura M.: Journal of Cardiography. 16. (1987)

小柳 S.；锅山 S.；Ohzono K.；竹下 A.；中村 M.：心电图杂志。