Coronary Circulation-Cardiac Mechanics Coupling

在脊椎动物中，有两种心肌，致密膜和海绵膜，它们与血液供应系统，即冠状动脉和窦状动脉循环有关。我们分析了大鼠和青蛙心脏舒张末期压力-容积关系，包括心室几何形状和心肌壁被动材料特性的综合表达。青蛙海绵状心室比致密心肌组成的大鼠左心室具有更高的可扩展性。为了评估心力衰竭如何调节左心室几何形状，我们建立了一个动物模型，诱导和心脏特异性过表达Na^+/Ca^<2+>交换器（NCX1），该交换器在衰竭心肌细胞中上调。我们发现NCX1过表达小鼠出现同心圆肥大伴松弛异常。

In vertebrates, there are two kinds of myocardium, compacta and spongiosa, which are associated with blood supply systems i.e. coronary and sinusoidal circulation. We analyzed the ventricular end-diastolic pressure-volume relationships in rat and frog heart that include integrated expression of chamber geometry and passive material properties of myocardial wall. Frog spongy ventricles showed higher expandability than rat left ventricles composed of compact myocardium. To assess how left ventricular geometry is regulated in heart failure, we generated an animal model of inducible and cardiac specific over-expression of Na^+/Ca^<2+> exchanger (NCX1) which is up-regulated in failing cardiac myocyte. We found that NCX1 over-expressing mice developed concentric hypertrophy with relaxation abnormality.