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Research for splinctein mechanism of lower esophagus in children

儿童下段食管夹板蛋白机制研究

基本信息

批准号：
61570603
负责人：
TAKAHASHI Hideyo
金额：
$ 1.28万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570603/
关键词：
Children Gastroesophageal reflux esophageal manometry 24 hour lower exphageal pH momitoring 食道胃接合部食道内圧食道内pH測定自動計測フーリエ変換 low compriance pump コンピュータ

项目摘要

The purpose of this study was to investigate the mechanisms of lower esophageal sphincter and its dysfunction in children by means of esophageal manometric study and 24 hour esophageal pH monitoring.1.The method of esophageal pH monitoring for children was established,and monitoring system was computerized. The system composed of pH glass electrode,pH amplifier,A-D converter,and computer.The pH electrode was positioned 2cm above the lower esophageal sphincter,and pH data was collected for 24 hours(sampling interval,2sec.).All data were stored in computer,and analysed automatically after the examination was finished by comuter system.2.GER,pyloric stenosis,hiatus hernia cases were studied by esophageal manometry and pH monitoring.Hiatal hernia case showed disturbance in manometric findings.In pyloric stenosis severe gastro esophageal reflux was existed,but esophageal clearance was maintained,and pH study findings recover only one week after surgical repair.In GER case pH monitoring was correlated with severity of the symptoms.3.Radiological evaluation of gastro esophageal reflux was estimated statistically by quantification theory.Grade of reflux,patulous hiatus,delayed reflux had correlation with pH monitoring.4.The histogram of pH data and reflux duration were edxamined.The pattern of the pH histogram was different when the cause of reflux was different.

本研究旨在通过食道测压和24小时食道pH监测，探讨儿童下食道括约肌及其功能障碍的发病机制。1.建立了儿童食道pH监测方法，并将监测系统计算机化。该系统由pH玻璃电极、pH放大器、A/D转换器和计算机组成。pH电极放置在下食道括约肌上方2 cm处，24小时(采样间隔2秒)采集pH数据。所有数据存储在计算机中，并在检查完成后由计算机系统自动分析。2.对GER、幽门狭窄、裂孔疝气患者进行食道测压和pH监测。食道裂孔疝气患者存在测压障碍。幽门狭窄患者存在严重的胃食道反流，但维持食道清扫。3.胃食道反流的放射学评价采用数量化理论，反流程度、扩张裂孔、延迟反流与pH监测有相关性。4.对pH数据直方图和反流持续时间进行编辑，不同原因引起反流的原因不同，pH直方图模式不同。