A study on serum lipid levels and blood rheology in chronic occlusive arterial disease

慢性闭塞性动脉疾病的血脂水平和血液流变学研究

• 批准号: 61570604
• 负责人: MISHIMA Yoshio
• 金额: $ 1.47万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570604/
• 关键词: arterioscrelotic obliteration (ASO); atherosclerosis; endothelial injury; 内膜肥厚; 閉塞性動脈疾患; 経皮的血管形成術; 抗血小板剤; 血管内皮損傷と内膜肥厚; 高コレステロール血症; 血管吻合部晩期閉塞症; 血中脂質; 高トリグリセリド血症; リポ蛋白分画; 末梢閉塞型動脈硬化症

(1) For analysis and examination of serum lipid, we selected 40 patients from those with ASO who had been treated in our hospital. As for tatal cholesterol in our study, there was no noticeable difference between the patient and control groups. ASO group exhibited high triglyceride levels and increased pre- lipo-protein, namely, increased VLDL cholesterol. This study results suggest that hyper lipidemia associated with elevated VLDL cholesterol could play a more important role in pathogenesis of ASO. (2) A study on serum lipid and atherosclerosis in experimental animal. It shows that high-cholesterol diet proceed the intimal prolifilation and atherosclerotic change at the anastomotic lesion. It suggests that serum cholesterol level is an important factor of the atheroscrelosis. (3) A study on endothelial injury and antiplatelet drug. After endotherial injury, intimal prolifilation was shown. Smooth muscle cell prolifetation is one of the major factor, but there was no difference between control group and drug diet group.

（1）为了分析和检查血清脂质，我们从医院接受治疗的ASO患者中选择了40名患者。至于塔塔尔胆固醇在我们的研究中，患者和对照组之间没有明显的差异。 ASO组表现出较高的甘油三酸酯水平，并增加了脂蛋白蛋白，即VLDL胆固醇升高。这项研究的结果表明，与VLDL胆固醇升高有关的高脂质血症在ASO发病机理中可能起更重要的作用。 （2）一项关于实验动物血清脂质和动脉粥样硬化的研究。它表明，高胆固醇饮食在吻合病变时进行了内膜增殖和动脉粥样硬化的变化。这表明血清胆固醇水平是动脉粥样硬化的重要因素。 （3）关于内皮损伤和抗血小板药物的研究。触及损伤后，显示了内膜增殖。平滑肌细胞增殖是主要因素之一，但对照组和饮食饮食组之间没有差异。

项目成果

三島好雄,岡早百合: 臨床医. 14. 405-406 (1988)

三岛芳夫，冈小百合：临床医生。14. 405-406 (1988)

三島好雄: 臨床成人病. 18. 53-57 (1988)

三岛芳雄：临床成人疾病。18. 53-57 (1988)

仁瓶善郎, 三島好雄: 医学のあゆみ. 140. 741-743 (1987)

Yoshiro Nibe，Yoshio Mishima：医学史 140. 741-743 (1987)。

三島好雄: "今日の治療指針「動脈塞栓症・血栓症」" 医学書院, 2 (1987)

三岛芳夫：“当今的治疗指南‘动脉栓塞和血栓形成’”Igakushoin，2 (1987)

三島好雄: みどり. 3. 28-29 (1987)

三岛芳雄：绿。3.28-29（1987）