Joint Study on familial Adenomatous polyposis

家族性腺瘤性息肉病联合研究

基本信息

批准号：
04045020
负责人：
MISHIMA Yoshio
金额：
$ 5.57万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

Purpose and Methods : Epidemiological, molecular genetic and clinical study on familial adenomatous polyposis (FAP) was intended between Japan and China. Know how about molecular biology, method of registration of FAP,materials need for molecular biology was provided from Japan. Japan side learned about the situation in China about research and clinic of FAP as well as general colorectal cancer.Results : Colorectal cancer incidence model in FAP and the general population was proposed (J Epidemiol 3 : 109,1993). The relative mortality from hepatoblastoma was 176 (95% CI 36-515) in young first degree relatives of FAP patients (Cancer 73 : 2065,1994). Relative mortality of periampullary cancer in FAP was 250 (95% CI 183-214) (Ann Surg 217 : 101,1992). Early detection of periampullary cancer was proved to be effective because it can be treated by local excision in an early stage (J Am Coll Surg 179 : 462,1994). Factors affecting the risk of cancer in the preserved rectum was clarified (Dis Colon Rectum 37 : 1024,1994). It was confirmed that both APC allelic changes are necessarry for adenomatous change of colorectal mucosa as well as desmoid tumor (Cancer Research 53 : 5079,1993, Cancer Research 54 : 3011,1994).In China, colorectal caner was the fifth among cancer deaths, and clinical investigation for FAP was not enough. Possibility of difference of mutation in APC gene between Japan and China was discussed. Several genetic mutations (p53, ras and others) in colorectal cancer was manifested by our help (Chin J Med 73 : 484,1994, Chin J Oncol, 1995, in printing). Loss of heterogeneity of APC gene in colorectal cancer was detected in 40% in China, and this was compatible with Japanese results of 44% in FAP and 48% in sporadic colorectal cancer.We had mutual understanding in basic and clinical situation of colorectal cancer and FAP.Considerable progress was achieved especially epidemiological and molecular biological study in Japan.

目的和方法：日本和中国之间的流行病学，分子遗传和临床研究。知道分子生物学，FAP登记方法如何，日本提供了分子生物学的材料。日本方面了解了中国关于FAP研究和诊所以及一般结直肠癌的情况。提议：FAP中的结直肠癌发病率模型和一般人群提出了（J Epidemiol 3：109,1993）。在FAP患者的年轻一级亲戚中，肝母细胞瘤的相对死亡率为176（95％CI 36-515）（癌症73：2065，1994）。在FAP中，闭疟疾癌的相对死亡率为250（95％CI 183-214）（Ann Surg 217：101,1992）。事实证明，早期检测到周期癌是有效的，因为它可以在早期的局部切除（J Am Coll Surg 179：462，1994）进行治疗。阐明了影响保留直肠癌风险的因素（Dis Colon Rectum 37：1024，1994）。据证实，APC等位基因的两种变化都是必需的结直肠粘膜和脱粘性肿瘤的腺瘤变化（癌症研究53：5079,1993，癌症研究54：3011,1994）。在中国，结直肠癌是癌症死亡人物中的第五次，以及FAP的临床研究中是第五次。讨论了日本和中国之间APC基因突变差异的可能性。我们的帮助（Chin J Med 73：484,1994，Chin J Oncol，Chin J Oncol，1995年）在结直肠癌中的几个遗传突变（p53，Ras等）在印刷中。在中国的40％中检测到了大肠癌中APC基因异质性的丧失，这与日本FAP的日本结果兼容，在FAP中的结果为44％，零星结直肠癌的丧失。我们在结直肠癌和FAP的基本和临床状态中有着相互的了解。尤其是在日本的基本和临床状况中取得了可观的进步。