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Epidemiologic study of rheumatoid arthritis in the inhabitant of Kagoshima district.

鹿儿岛地区居民类风湿性关节炎的流行病学研究。

基本信息

批准号：
61570722
负责人：
SAKOU Takashi
金额：
$ 1.34万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570722/
关键词：
HLA Immunity Rheumatoid Factor Epidemiology 慢性関節リウマチ抗体価

项目摘要

Epidemiologic study of rheumatoid arthritis (RA) was carried out in Kagoshima district. Prevalence of RA was investigated in 3200 out of 4791 inhabitants of Yoshimatsu Town and 800 out of 8720 of Minamitane Town. RA (classical and definite) was found in 0.29% and 0.49% respectively.Serum rheumatoid factor (latex test) was positive in 4.0% (male 3.4%, female 4.5%) of 3200 normal subjects. The difference was not significant statistically. The frequency of latex test positive was in a increasing tendency. with aging. The onset of RA in 466 or our clinic, however, showed a peak in at the age of 40's with nearly normal distribution. From these facts, a small number of the subjects with latex test positive in general population may be predisposed to rheumatoid arthritis, but the great majority may be simply associated with physiologic change due to aging.On the other hand, latex test and haemagglutination test were studied in onejime area, the former was found positive in 4.2% and the latter in 4.4% out'of the 2095 normal subjects investigated. HLA complex could be analysed in 16 out of the 64 subjects with either of both tests positive. No significant difference was noted between this group and general Japanese population as control in HLA complex. DR4 was not marked characteristically in this group.

在鹿儿岛地区进行了类风湿性关节炎（RA）的流行病学研究。对吉松町 4791 名居民中的 3200 名居民和南种子町 8720 名居民中的 800 名居民进行了 RA 患病率调查。 RA（典型型和确诊型）分别为0.29%和0.49%。3200名正常受试者中血清类风湿因子（乳胶试验）阳性率为4.0%（男性3.4%，女性4.5%）。差异无统计学意义。乳胶检测阳性率呈上升趋势。随着衰老。然而，我们诊所的 466 例 RA 发病高峰出现在 40 岁，几乎呈正态分布。从这些事实来看，一般人群中少数乳胶检测呈阳性的受试者可能易患类风湿性关节炎，但绝大多数可能只是与衰老引起的生理变化有关。另一方面，在onejime地区对乳胶检测和血凝试验进行了研究，在调查的2095名正常受试者中，乳胶检测呈阳性的率为4.2%，后者为4.4%。 64 名受试者中，有 16 名受试者的 HLA 复合物可进行分析，且两项检测均呈阳性。该群体与作为对照的普通日本人群之间的 HLA 复合体没有显着差异。 DR4 在该组中没有特征性标记。