Defining pathways that control T cell lifespan for long-term immunity

定义控制 T 细胞寿命的途径以实现长期免疫

• 批准号: DP240102812
• 负责人: Prof William Heath
• 金额: $ 56.4万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102812
• 关键词: Defining; pathways; control; cell; lifespan

This project will investigate the cellular and molecular pathways regulating lifespan of tissue-resident memory T cells (Trm cells), a non-circulating T cell subset that play a crucial role in the frontline defence against infection. Significantly, how long Trm cells live is paramount to how long immunity is sustained. Using cutting-edge cellular and molecular techniques, the expected outcomes of this project include identification of the genes and processes that control lifespan. This should provide significant benefits in the basic knowledge of how longevity of immunity is regulated. This understanding will be useful for future immunotherapeutic applications, such as veterinary or human vaccines requiring maximal duration of immunity

该项目将研究调节组织驻留记忆T细胞（Trm细胞）寿命的细胞和分子途径，这是一种非循环T细胞亚群，在对抗感染的前线防御中发挥关键作用。值得注意的是，Trm细胞的存活时间对免疫力的持续时间至关重要。利用尖端的细胞和分子技术，该项目的预期成果包括识别控制寿命的基因和过程。这应该提供免疫力寿命是如何调节的基本知识的显着好处。这种理解将有助于未来的免疫学应用，例如需要最大免疫持续时间的兽医或人类疫苗