The effect of hypoxia on fetal Cardiovascular System

缺氧对胎儿心血管系统的影响

• 批准号: 61570811
• 负责人: MIYAKE Yoshiaki
• 金额: $ 1.41万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570811/
• 关键词: FHR; FBM; FM; Sleeping cycle; Accerelation (ACC); Decerelation (DCC); Vibroacoustic Stimulation test (VAST); Hypoxia; Norepinephrine (NE); Arginine Vasopressine (AVP); V.broaconstic Stimulation Test(VAS); AOP; SHR

1) Animal Experiment Fetal heart rate (FHR), EEG, ECG, Tracheal pressure and fetal blood pressure (FBP) recorded continiously by using sheep chronic prepartion model revealed the obvious changes of FBP, FHR, fetal breathing movement (FBM) as well as its quantitative and qualitative differences in each period of sleeping cycles. While the Accerelation (ACC) (amplitude more than 40bpm, duration more than 40sec) coincident with fetal movement, burst of fetal breathing movement (FBM) and increase of FBP were characteristic during low voltage high frequency (LVHF) sleep, the deccerelation (DCC) with fetal movement (FM) were characteristicaly increased in high voltage low frequency (HVLF) sleep and this tendency was more prominent in younger fetuses. Nor epinephrine (NE) and arginine vasopressin (AVP) increased during hypoxia were infused continuously to fetal lamb and abult domestic rabbits t clalify the effects of these hormones on fetal cardiovasuclar system. While Ne resulted in increase … More of FBP and decrease in FHR, AVP resulted in persistent increase in FBP and decrease in FHR and in its variability as well as marked inhibition of FBM.2) Human fetus FM. FBM and FHR were observed by using ultrasound and MT 320 fetal movement recorder during 28-40 gestational weeks. The amplitude and duration of ACC coincident with rolling movent were increased according to progress of gestaional weeks and that type of ACC was characteristic in active sleep. In order to cause a stress situation, 75Hz, 74db vibro-acoustic stimultion (VAST) was performed during the fetal heart rate monitoring. The majority of the fetuses reacted with an ACC in heart rate and the degree of reactivity varied with the weeks of advancement of pregnancy. Our responses were classified into 4 groups, consisting of 5 types. Type-1(ACC type) and type-2(tachycardia type) were in good prognosis. Type-3(triphasic type) was those with cord involvement (group2). Type-4 (DCC type) and type-5 (non-response type) had poor prognosis (group3,4). Less

1）动物实验利用绵羊慢性预备模型连续记录胎心率（FHR）、脑电图、心电图、气管压和胎儿血压（FBP），显示各睡眠周期期间FBP、FHR、胎儿呼吸运动（FBM）的明显变化及其量质差异。低电压高频 (LVHF) 睡眠期间，加速 (ACC)（振幅超过 40bpm，持续时间超过 40 秒）与胎动、胎儿呼吸运动爆发 (FBM) 和 FBP 增加是特征性的，而伴随胎动 (FM) 的减速 (DCC) 在高电压低频 (HVLF) 睡眠中特征性增加，这种趋势在 胎儿较年轻。将缺氧时增加的肾上腺素（NE）和精氨酸加压素（AVP）连续输注给胎羔和离体家兔，以阐明这些激素对胎儿心血管系统的影响。 Ne 导致 FBP 增加和 FHR 减少，而 AVP 导致 FBP 持续增加和 FHR 减少及其变异性以及 FBM 的显着抑制。2) 人类胎儿 FM。使用超声和MT 320胎动记录仪观察孕28-40周的FBM和FHR。与滚动运动一致的 ACC 的幅度和持续时间随着孕周的进展而增加，并且这种类型的 ACC 是主动睡眠的特征。为了造成压力情况，在胎心率监测期间进行75Hz、74db振动声刺激(VAST)。大多数胎儿对心率有 ACC 反应，反应程度随妊娠周数的变化而变化。我们的回答分为 4 组，由 5 种类型组成。 1型（ACC型）和2型（心动过速型）预后良好。 3型（三相型）是脊髓受累的患者（组2）。 4型（DCC型）和5型（无反应型）预后较差（组3，4）。较少的

项目成果

坂田寿衛、飯塚桜綾香、西島重信、上岡直樹、三宅良明、高木繁夫: ペリネイタル ケア (The Japanese Journal of perinatal Cave). 76. 61-68 (1988)

Hisae Sakata、Ayaka Iizuka Sakura、Shigenobu Nishijima、Naoki Kamioka、Yoshiaki Miyake、Shigeo Takagi：围产期护理（日本围产期杂志）76. 61-68 (1988)。

三宅 良明.村田 雄二.坂田 寿衛: 臨床婦人科産科. 39. 547-556 (1985)

三宅佑二。坂田久佐：临床妇产科。39。547-556（1985）

三宅 良明.坂田 寿衛: 日産婦誌.

三宅义明。坂田久佐：日产女性杂志。