Functional analysis of CCN2 as a metabolic supporter and potential clinical applications in chondrocyte regeneration

CCN 2作为软骨细胞再生代谢支持物的功能分析和潜在临床应用。本研究的目的是分析结缔组织生长因子（CCN 2）对软骨细胞整体代谢，特别是能量产生的影响以及与能量产生相关的分子基础。结果表明，CCN 2的缺乏导致软骨细胞中三磷酸腺苷（ATP）的量减少和糖酵解抑制。此外，CCN 2被证明是软骨细胞再生中产生ATP的代谢支持物。此外，骨关节炎（OA）模型中关节软骨再生的效果表明骨关节炎软骨治疗的未来临床应用。

Functional analysis and potential clinical applications of CCN2 as a metabolic supporter in chondrocyte regeneration. The purpose of this study was to analyze the influence of connective tissue growth factor (CCN2) on overall metabolism in chondrocytes, especially energy production and a molecular basis related to the energy production. The result revealed that the absence of CCN2 caused the decrease in the amount of adenosine triphosphate (ATP) in chondrocytes and suppression of glycolysis. Also, CCN2 was shown to be a metabolic supporter in chondrocyte regeneration producing ATP. Furthermore, the effect of articular cartilage regeneration in an osteoarthritis (OA) model suggested future clinical application for osteoarthritis cartilage treatment.