Investigation of the Inner Ear Fluids by Means of Measurements of Blood Flow, Oxygen Tension and Hydrostatic Pressure

1.同时测定豚鼠内淋巴和外淋巴的氢清除率(HC)，并计算HC的T1/2作为内耳液代谢的指标。结果表明：1)内淋巴HC的T1/2明显短于外淋巴液。2)无论是内淋巴还是外淋巴，速尿对T_1/2HC均无明显影响。3)甘油显著缩短内淋巴液和外淋巴液中HC的T1/2。用伺服零位测压系统同时测量了豚鼠内淋巴和外淋巴的静水压力。在生理条件下，内淋巴和外淋巴的静水压力没有差异。在缺氧期间和服用甘油后，两种压力之间也没有差异。

1. Hydrogen clearance (HC) of the endolymph and perilymph in guinea pigs was simultaneously measured and T1/2 of HC was calculated as an index of the metabolism of the inner ear fluids. The results are as follows: 1)T1/2 of HC of the endolymph was significantly shorter than that of the perilymph. 2) Furosemide induced no significant change of T1/2 HC of neither the endolymph nor the perilymph. 3) Glycerol significantly shortened T1/2 of HC in both of the endolymph and perilymph.2. Hydrostatic pressures of the endolymph and perilymph in guinea pigs were measured simultaneously using servo-nulling pressure measuring system. On physiological condition, there was no difference between the hydrostatic pressures of the endolymph and erilymph. During anoxia and after the administration of glycerol, there was no difference between the two pressures, also.