Investigation of the Inner Ear Fluids by Means of Measurements of Blood Flow, Oxygen Tension and Hydrostatic Pressure

通过测量血流量、氧张力和静水压来研究内耳液体

• 批准号: 61570825
• 负责人: KISHIMOTO Seiji
• 金额: $ 1.22万
• 依托单位: Kochi Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570825/
• 关键词: Inner ear fluids; Hydrogen clearance; Hydrostatic pressure; Oxygen tension; 浸透圧利尿剤; 内耳血流量; 内耳液圧

1. Hydrogen clearance (HC) of the endolymph and perilymph in guinea pigs was simultaneously measured and T1/2 of HC was calculated as an index of the metabolism of the inner ear fluids. The results are as follows: 1)T1/2 of HC of the endolymph was significantly shorter than that of the perilymph. 2) Furosemide induced no significant change of T1/2 HC of neither the endolymph nor the perilymph. 3) Glycerol significantly shortened T1/2 of HC in both of the endolymph and perilymph.2. Hydrostatic pressures of the endolymph and perilymph in guinea pigs were measured simultaneously using servo-nulling pressure measuring system. On physiological condition, there was no difference between the hydrostatic pressures of the endolymph and erilymph. During anoxia and after the administration of glycerol, there was no difference between the two pressures, also.

1.本文同时测定了豚鼠内淋巴和外淋巴的氢清除率（HC），并计算HC的T_（1/2）作为内耳液代谢的指标。结果表明：（1）内淋巴HC的T1/2明显短于外淋巴HC的T1/2。2)速尿对内淋巴和外淋巴的T1/2 HC均无明显影响。3)甘油能显著缩短内淋巴和外淋巴HC的T1/2.采用伺服调零压力测量系统同时测量豚鼠内淋巴和外淋巴的流体静压。在生理条件下，内淋巴和外淋巴的静水压力无明显差异。在缺氧期间和甘油给药后，两种压力之间也没有差异。

项目成果

木村正,竹田泰三,岸本誠司,鎮西邦彦,齋藤春雄: Audiology Japan. 30. 605-606 (1987)

Tadashi Kimura、Taizo Takeda、Seiji Kishimoto、Kunihiko Chinzei、Haruo Saito：日本听力学。 30. 605-606 (1987)

T. Takeda, S. Takeuchi, K. Chinzei and H. Saito: "Simultaneous Measurements of the Hydrostatic Pressure of the Endolymph and Perilymph" Equilibrium Research. Suppl. 2. 26-30 (1987)

T. Takeda、S. Takeuchi、K. Chinzei 和 H. Saito：“内淋巴和外淋巴静水压的同时测量”平衡研究。

T. Kimura, T. Takeda, S. Kishimoto, K. Chinzei and H. Saito: "The Hydrogen Clearance of the Endolymph and Perilymph" Equilibrium Research. 47. (1988)

T. Kimura、T. Takeda、S. Kishimoto、K. Chinzei 和 H. Saito：“内淋巴和外淋巴的氢清除”平衡研究。

T. Kimura, T. Takeda, S. Kishimoto, K. Chinzei and H. Saito: "Measurements of Hydrogen Clearance of the Endolymph and Perilymph" Audiology Japan. 30. 605-606 (1987)

T. Kimura、T. Takeda、S. Kishimoto、K. Chinzei 和 H. Saito：“内淋巴和外淋巴氢清除率的测量”日本听力学。

S. Takeuchi, T. Takeda, S. Kishimoto and H. Saito: "The Hydrostatic Pressures of the Endolymph and Perilymph" Equilibrium Research. 47. (1988)

S. Takeuchi、T. Takeda、S. Kishimoto 和 H. Saito：“内淋巴和外淋巴的静水压力”平衡研究。