HYDROGEN CLEARANCE & TRACER DIFFUSION METHODS FOR DETERMINING CEREBRAL BLOOD FLOW

氢间隙

• 批准号: 3945317
• 负责人: T S NOWAK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3945317
• 关键词: blood flow measurement; cerebral cortex; corpus striatum; diagnosis quality /standard; radionuclide diagnosis; radiotracer

Recent results in the gerbil have demonstrated dramatic reductions of hemispheric blood flow, assessed by a (3H) nicotine tracer diffusion method, following placement of a single electrode in striatum for the purpose of measuring blood flow by the alternative hydrogen clearance method. Blood flow in cortical regions of the impaled hemisphere is reduced several-fold relative to the opposite hemisphere, returning gradually to control levels by 3-6 hr. Blood flow measurements in striatum, obtained with the implanted hydrogen clearance electrode, also increases two- fold during 6 hr after placement. These results demonstrate that significant reductions of normal blood flow arise following acute placement of electrodes for hydrogen clearance measurements in the gerbil, although chronic implantation may still provide valid measurements. Measurements obtained in cats several years ago with chronically implanted hydrogen electrodes gave unexpectedly high values for striatal blood flow, attributed at that time to the light anesthesia which could be used at the time of measurement. These results will be systematically reinvestigated in view of the current findings in the gerbil.

最近在沙鼠身上的实验结果显示 通过a（3 H）尼古丁评估的半球血流量减少 示踪剂扩散法，在放置单个电极后 在纹状体中，用于测量血流量， 替代氢清除方法。 皮质血流量 被刺穿的半球的区域相对于被刺穿的半球的区域减少了数倍， 到对侧半球，逐渐回到控制水平 纹状体中的血流量测量，用 注入的氢清除电极，也增加了两个- 放置后6小时内折叠。 这些结果证明 在急性心肌梗死后， 氢清除测量电极的位置 沙鼠，尽管慢性植入仍然可以提供有效的 测量. 几年前在猫中获得的测量结果， 植入的氢电极给出了出乎意料的高值， 纹状体血流，当时归因于轻度麻醉 其可以在测量时使用。 这些结果 将系统地重新调查，鉴于目前的 沙鼠的发现。