Pathophysiological studies of platelet-associated immunoglobulins.

血小板相关免疫球蛋白的病理生理学研究。

基本信息

  • 批准号:
    61571106
  • 负责人:
  • 金额:
    $ 1.34万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1986
  • 资助国家:
    日本
  • 起止时间:
    1986 至 1987
  • 项目状态:
    已结题

项目摘要

Idiopathic thrombocytopenic purpura (ITP) is due to an antibody against a platelet-associated antigen with subsequent platelet phagocytosis by the reticuloendotherial system. Therefore,ITP is one of the autoimmune diseases and the relationship between ITP and systemic lupus erythematosus (SLE) has received much attention. So, we measured the values of platelet-associated IgG (PAIgG), PAIgM , PAIgA and PAC3 in both diseases and compared these values.In the patients of ITP, the degree of thrombocytopenia and shortening of the intravascular survival of platelets is in most cases higher than in those of SLE. While , in the patients of SLE , the fequency of elevated PAC3 is lower than in those of ITP. In the patients of either , elevation of IgG antiplatelet antibodies in combination with IgA , IgM , C3 was better correlated with the level of thrombocytopenia than elevation of only these antibodies.Therefore , it is suggested that the simultaneous measurement of these antibodies is useful in the clinical study of both diseases.While , there are many assays for the measurement of PAIgG , normal values of PAIgG are variable according to the different assays. We investigated the assay of PAIgG by the Micro ELISA system from 1986,and established a reliable method. So , we compared these results with those of the immunoperoxidase method. We found , these results crrelated closely with each other only when the same enzyme labeled antibody was used.Moreover , we attempted to establish a simple and sensitive assay of platelet-bound IgG (PBIgG) for the patients who received many platelet transfusions, and developed a simple method relying on the naked eye using avidin -biotin-peroxidase complex.
特发性血小板减少性紫癜(ITP)是由于抗血小板相关抗原的抗体引起的,随后血小板被网状内皮系统吞噬。因此,ITP是一种自身免疫性疾病,其与系统性红斑狼疮(SLE)的关系备受关注。因此,我们测定了血小板相关IgG(PAIgG)、PAIgM、PAIgA和PAC_3在两种疾病中的值,并进行了比较。而在SLE患者中,PAC 3升高的频率低于ITP患者。在两种疾病中,IgG抗血小板抗体与伊加、IgM、C_3的联合升高与血小板减少的相关性比单独升高更好,因此,同时测定这些抗体对两种疾病的临床研究是有用的。PAIgG的正常值根据不同的测定而变化。我们从1986年开始研究用微量ELISA系统测定PAIgG,建立了一种可靠的方法。因此,我们将这些结果与免疫过氧化物酶法的结果进行了比较。我们还尝试建立一种简便、灵敏的测定多次血小板输注病人血小板结合IgG(PBIgG)的方法,并建立了一种简便的肉眼检测法,即用亲和素-生物素-过氧化物酶复合物。

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hatsue OGAWARA , et al: "Quantitative assay of immunoglobulin G by means of competitive enzyme immunoassay." The Annual Reports of College of Medical Care and Technology Gunma University. 7. 51-55 (1986)
Hatsue OGAWARA 等人:“通过竞争性酶免疫测定法对免疫球蛋白 G 进行定量测定。”
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    0
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  • 通讯作者:
Hatsue OGAWARA , et al: "A comparative study of two methods for the determination of platelet associated immunoglobulin G (PAIgG)." The Annual Reports of College of Medical Care and Technology. 8. 75-80 (1987)
Hatsue OGAWARA 等人:“两种测定血小板相关免疫球蛋白 G (PAIgG) 方法的比较研究。”
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    0
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  • 通讯作者:
小河原はつ江,柴川直子,村上博和,土屋純,中里享美: 群馬大学医療技術短期大学部紀要. 7. 51-55 (1986)
Hatsue Okawara、Naoko Shibakawa、Hirokazu Murakami、Jun Tsuchiya、Yumi Nakazato:群马大学医学技术学院通报。 7. 51-55 (1986)
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    0
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Hatsue OGAWARA , et al: "Study on the change of PAIgG, PAIgM, PAIgA and PAC3 in patients with idiopathic thrombocytopenic purpura and systemic lupus erythematosus."
Hatsue OGAWARA,等:“特发性血小板减少性紫癜和系统性红斑狼疮患者PAIgG、PAIgM、PAIgA和PAC3变化的研究”。
  • DOI:
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    0
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  • 通讯作者:
小河原はつ江,村上博和,須永ゆかり,大竹晴美,土屋純,: 群馬大学医療技術短期大学部紀要. 8. 75-80 (1987)
Hatsue Okawara、Hirokazu Murakami、Yukari Sunaga、Harumi Otake、Jun Tsuchiya:群马大学医学技术学院通报。 8. 75-80 (1987)
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TSUCHIYA Jun其他文献

TSUCHIYA Jun的其他文献

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{{ truncateString('TSUCHIYA Jun', 18)}}的其他基金

First principles investigation of the elasticity of serpentine minerals
蛇纹石矿物弹性的第一性原理研究
  • 批准号:
    24740357
  • 财政年份:
    2012
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
A study of performance cross-country skiing movement
越野滑雪运动性能研究
  • 批准号:
    23650396
  • 财政年份:
    2011
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
First principles investigation on the structure and vibrational properties of high pressure phase of olivine
橄榄石高压相结构与振动特性的第一性原理研究
  • 批准号:
    21740380
  • 财政年份:
    2009
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Joint torque and power analysis of giant swing elements in Parallel bars in Gymnastics
体操双杠巨型摆动元件关节扭矩与功率分析
  • 批准号:
    15500463
  • 财政年份:
    2003
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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