Search for Antifungal Substances from Marine Invertebrates

从海洋无脊椎动物中寻找抗真菌物质

• 批准号: 62560206
• 负责人: FUSETANI Nobuhiro
• 金额: $ 1.6万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62560206/
• 关键词: Marine Invertebrates; Spnges; Gorgonians; Antifungal Activity; Candida; Mortierella; Penicillum; Petrosia; Mycale; Acalycigorgia; Polyacetylene Alcohol; Acalycixeniolide; トゲナシヤギ; ノルジテルペン; Petrosia; ポリアセチレンアルコール

Marine invertebrates, mainly sponges and coelenterates (143 specimens) have been collected from various places including Izu peninsula, Hachijo Island, Kii Peninsula and Shikoku coasts, and examined for antifungal activity against Candida albicans, Mortierella ramannianus and Penicillium chrysogenum. Many sponges were found to be promising as a source of antifungal agents.The following 9 antifungal substances have been isolated from active specimens and their structures elucidated mainly by spctroscopic analyses: Petrosynol (1) from a sponge Petrosia sp. collected in Hachijo Island, acalycixeniolides A (2) and B (3) from the gorgonian Acalycigorgia inermis collected in Izu Peninsula, ginamallene (4), acalycixeniolides B' (5) and C (6) from Acalycigorgia sp., and mycalolides A - C (7 - 9) from a sponge of genus Mycale collected in Kii Peninsula.KA

从日本伊豆半岛、八丈岛、纪伊半岛、四国沿岸等地采集了143种海洋无脊椎动物，主要是海绵和腔肠动物，进行了对白色念珠菌、拉曼被孢霉和产黄青霉的抗真菌活性研究。许多海绵被发现是有希望作为抗真菌剂的来源，以下9种抗真菌物质已从活性样品中分离出来，它们的结构主要通过光谱分析确定：从八丈岛采集的海绵岩藻属的岩藻醇（Petrosynol）（1），从伊豆半岛采集的柳珊瑚无刺无萼柳珊瑚（Acalycigorgia inermis）的无萼异甾内酯A（2）和B（3），ginamallene（4），Acalycixeniolides B'（5）和C（6）来自Acalycigorgia sp.，和采自纪伊半岛的Mycale属海绵的Mycalolides A-C（7 - 9）。KA

项目成果

N.Fusetani.: Terahedron. 45. inpress (1989)

N.Fusetani.：四面体。

N. Fusetani: "Acalycixeniolides, novel norditerpenes which inhibit cell diision of fertilized starfish eggs, from the gorgonian Acalycigorgia inermis." Tetrahedron Lettrs. 28. 5837-5840 (1987)

N. Fusetani：“Acalycixeniolides，一种新型去甲二萜，可抑制受精海星卵的细胞分裂，来自柳珊瑚 Acalycigorgia inermis。”