Search for Antifungal Substances from Marine Invertebrates

在伊豆半岛、八条岛、喜井半岛和四国海岸等地采集了以海绵和腔肠动物为主的海洋无脊椎动物143只标本，检测了对白色念珠菌、拉曼尼摩氏菌和青霉菌的抗真菌活性。许多海绵被发现有希望作为抗真菌剂的来源。从活性标本中分离到9种抗真菌物质，并通过光谱分析对其结构进行了初步鉴定：八市岛海绵Petrosia sp.中的Petrosynol(1)，伊豆半岛柳珊瑚acalyciorgia inermis中的acalycixeniolides a(2)和B (3)， Kii半岛Mycale属海绵中的ginamallene(4)、acalycixeniolides B'(5)和C (6)， Kii半岛Mycale属海绵中的mycalolides a - C（7 - 9）。卡

Marine invertebrates, mainly sponges and coelenterates (143 specimens) have been collected from various places including Izu peninsula, Hachijo Island, Kii Peninsula and Shikoku coasts, and examined for antifungal activity against Candida albicans, Mortierella ramannianus and Penicillium chrysogenum. Many sponges were found to be promising as a source of antifungal agents.The following 9 antifungal substances have been isolated from active specimens and their structures elucidated mainly by spctroscopic analyses: Petrosynol (1) from a sponge Petrosia sp. collected in Hachijo Island, acalycixeniolides A (2) and B (3) from the gorgonian Acalycigorgia inermis collected in Izu Peninsula, ginamallene (4), acalycixeniolides B' (5) and C (6) from Acalycigorgia sp., and mycalolides A - C (7 - 9) from a sponge of genus Mycale collected in Kii Peninsula.KA