Efficient Utilization of Fisheries Biproducts. Exploration of miomedial Resoures from Deep-Sea Spong

为了探索从深海海绵中发现具有生物医学重要性的新化合物的可能性，我们在大岛附近的新根收集了78个样品，并检查了其提取物的生物活性。超过70%的提取物表现出细胞毒性，抗菌或酶抑制活性，证明了深海海绵在天然产物药物发现中的重要性。从采集的海绵中分离得到以下化合物：1.日本盘皮海绵（Discodermia japonica）中的Theopederin K; 2.伸展斯托埃巴（Stoeba extensa）中的Shinsonefuran; 3. Poecillastra sp.中的新大环内酯类化合物。

In order to explore the possibility of discovering new compounds with biomedical importance from deep-sea sponges, we collected 78 samples at Shinsone, near Oshima Island and examined the biological activities of their extracts. More than 70% of the extracts exhibited either cytotoxic, antimicrobial, or enzyme inhibitory activity, demonstrating the importance of deep-sea sponges in natural products drug discovery. We have isolated the following compounds from the collected specimens.1.Theopederin K from Discodermia japonica2.Shinsonefuran from Stoeba extensa3.Novel macrolides from Poecillastra sp.Isolation of cytotoxic constituents from another deep-sea sponge collected off Heda, Izu, is in progress.