Efficient Utilization of Fisheries Biproducts. Exploration of miomedial Resoures from Deep-Sea Spong

渔业副产品的高效利用。

• 批准号: 14360119
• 负责人: FUSETANI Nobuhiro
• 金额: $ 11.01万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14360119/
• 关键词: Deep-Sea; Sponge; Biomedical; Bioactive; Cytotoxic; Structure elucidation; 深海海綿; 漁業混獲物; theopederin; セスタテルペン; マクロライド; 構造解析; 抗菌・抗カビ性; 酵素阻害活性; タカシガニ漁

In order to explore the possibility of discovering new compounds with biomedical importance from deep-sea sponges, we collected 78 samples at Shinsone, near Oshima Island and examined the biological activities of their extracts. More than 70% of the extracts exhibited either cytotoxic, antimicrobial, or enzyme inhibitory activity, demonstrating the importance of deep-sea sponges in natural products drug discovery. We have isolated the following compounds from the collected specimens.1.Theopederin K from Discodermia japonica2.Shinsonefuran from Stoeba extensa3.Novel macrolides from Poecillastra sp.Isolation of cytotoxic constituents from another deep-sea sponge collected off Heda, Izu, is in progress.

为了探索从深海海绵中发现具有重要生物医学意义的新化合物的可能性，我们在大岛附近的Shinsone收集了78个样品，并检测了其提取物的生物活性。超过70%的深海海绵提取物具有细胞毒性、抗菌活性或酶抑制活性，证明了深海海绵在天然产物药物发现中的重要性。我们从所收集的标本中分离出下列化合物：取自日本松皮虫的开皮素K。Shinsonefuran源自Stoeba extensa3。来自Poecillastra的新大环内酯类化合物。从伊豆禾达的另一种深海海绵中分离细胞毒性成分的研究正在进行中。

项目成果

Phuwapraisirisan et al.: "Shinsonefuran, a cytotoxic furanosesterterpene with a novel carbon skeleton, from the deep-sea sponge stoeba extensa."Tetrahedron Lett.. 45. 2125-2128 (2004)

Phuwapraisirisan 等人：“Shinsonefuran，一种具有新型碳骨架的细胞毒性呋喃酯萜，来自深海海绵 stoeba extensa。”Tetrahedron Lett.. 45. 2125-2128 (2004)

P.Phuwapuraisirisan, S.Matsunaga他2名: "Shinsonefuran, a cytotoxic furanosesterterpene with a novel carbon skeleton, from a deep-sea sponge Stoeba extensa."Tetrahedron Letters. 45・10. 2125-2128 (2004)

P.Phuwapuraisirisan、S.Matsunaga 和其他 2 人：“Shinsonefuran，一种来自深海海绵 Stoeba extensa 的细胞毒性呋喃酯萜。”Tetrahedron Letters 45・10 (2004)。

Phuwa@raisirisan, P., et al.: "Shinsonefuran, a cytotoxic furanosestertenpene with a novel carbon skelton, from the deep-sea sponge Stoeba extensa"Tetrahedron Letters. 45. 2125-2128 (2004)

Phuwa@raisirisan, P., et al.：“Shinsonefuran，一种具有新型碳骨架的细胞毒性呋喃酮酯烯，来自深海海绵 Stoeba extensa”四面体快报。