Mechanisms of suppression of gonadotrophins secretion by suckling stimuli in lactating rats.

哺乳期大鼠哺乳刺激抑制促性腺激素分泌的机制。

基本信息

  • 批准号:
    62560291
  • 负责人:
  • 金额:
    $ 1.34万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1987
  • 资助国家:
    日本
  • 起止时间:
    1987 至 1989
  • 项目状态:
    已结题

项目摘要

The roles of corticotrophin-releasing factor (CRH) and beta-endorphin in the suppression of LH and FSH secretion during lactation were investigated using ovariectomized lactating rats separated from their litters overnight. Within 1 h of returning the pups to their mothers a marked fall in plasma LH concentration and a large increase in plasma prolactin were noted. However, resuckling caused no significant change in plasma concentration of FSH until 12 h after the return of the litter but a significant decline occurred thereafter. Twenty-four hours after removal of the litter, a single i.v. injection of 200mul anti-LHRH serum caused similar changes in plasma concentrations of LH and FSH observed in nursing rats during suckling. These results suggest that the suckling stimulus itself is responsible for the suppression of LH as well as FSH, via inhibition of the secretion of LHRH. Twenty-four hours after removal of the litter, a single intracerebroventricular (i.c.v.) injection of either 10mug CRH or beta- endorphin resulted in a rapid decrease in plasma LH. Only beta-endorphin caused a marked increase in plasma levels of prolactin within 1 h whereas FSH was less affected by either hormone. Repeated i.c.v. administration of 10mug CRH or beta-endorphin at 6 h intervals caused a prolonged inhibition of LH as well as FSH secretion during 48 h, with beta-eridorphin being less effective than CRH.These results demonstrate that the suckling stimulus alone suppressed the secretion of both LH and FSH, and suggest that this effect may be mediated by the inhibition of LHRH secretion from the hypothalamus. They also suggest that the suckling-induced inhibition of LHRH may be primarily mediated by endogenous CRH,and opioid peptides.
用隔夜分离的去卵巢哺乳大鼠研究促肾上腺皮质激素释放因子(CRH)和β-内啡肽在抑制哺乳期黄体生成素和卵泡刺激素分泌中的作用。在将幼崽送回母亲身边的1小时内,血浆黄体生成素浓度显着下降,血浆催乳素浓度显着升高。然而,重新哺乳直到产仔后12h才引起血浆FSH浓度的显著变化,但此后显著下降。在清除猫砂24小时后,进行单次静脉注射。在哺乳过程中,注射200mul抗LHRH血清可引起哺乳大鼠血浆中促黄体生成素和卵泡刺激素浓度的类似变化。这些结果表明,哺乳刺激本身通过抑制LHRH的分泌来抑制促黄体生成素和卵泡刺激素。移除猫砂24小时后,单侧脑室(i.c.v.)注射促肾上腺皮质激素释放激素或β-内啡肽均可使血浆黄体生成素迅速下降。在1h内,只有β-内啡肽引起血浆催乳素水平显着升高,而FSH受这两种激素的影响都较小。重复一次静脉注射。每隔6h给药10mug CRH或β-内啡肽,48h内对黄体生成素和卵泡刺激素的分泌均有较长时间的抑制作用,而β-埃立吗啡的抑制作用弱于促肾上腺皮质激素释放激素。结果表明,哺乳刺激对黄体生成素和卵泡刺激素的分泌均有抑制作用,提示这种作用可能是通过抑制下丘脑的促黄体生成素释放来实现的。他们还提示,哺乳对LHRH的抑制可能主要是由内源性CRH和阿片肽介导的。

项目成果

期刊论文数量(15)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K. Taya;S. Sasamoto: Endocrinologica Japonica. 35. (1988)
K.塔亚;S.
  • DOI:
  • 发表时间:
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  • 影响因子:
    0
  • 作者:
  • 通讯作者:
K.Taya and S.Sasamoto: "Selective release of FSH in lactating rats during the period of follicular atresia induced by the administration of antiserum to LH-releasing hormone." Journal of Endocrinology. 118. 455-464 (1988)
K.Taya 和 S.Sasamoto:“在给予 LH 释放激素抗血清诱导的卵泡闭锁期间,哺乳大鼠中 FSH 的选择性释放。”
  • DOI:
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  • 影响因子:
    0
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  • 通讯作者:
K.Taya and S.Sasamoto: "Involvement of the adrenal gland in the suckling-induced decrease in LH and FSH secretion and the concomitant indrease in prolactin secretion in the rat." Journal of Endocrinology. 125. (1990)
K.Taya 和 S.Sasamoto:“肾上腺参与哺乳引起的大鼠 LH 和 FSH 分泌减少以及随之而来的催乳素分泌增加。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
K.Taya;S.Sasamoto: Journal of Endocrinology. 118. 455-464 (1988)
K.Taya;S.Sasamoto:内分泌学杂志。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
K.Taya;S.Sasamoto: Jurnal of Endocrinology. 120. (1989)
K.Taya;S.Sasamoto:内分泌学杂志。
  • DOI:
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  • 影响因子:
    0
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TAYA Kazuyoshi其他文献

TAYA Kazuyoshi的其他文献

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{{ truncateString('TAYA Kazuyoshi', 18)}}的其他基金

Studies on toxic effects of nitrophenols contained in degradation products of insecticide in reproduction and promoting activity in lunge cancer
杀虫剂降解产物中硝基酚的生殖毒性作用及对肺癌的促进作用研究
  • 批准号:
    18310044
  • 财政年份:
    2006
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Studies on neuroendocrinological mechanisms of memory in the Hatano rats
波多野大鼠记忆的神经内分泌机制研究
  • 批准号:
    13660296
  • 财政年份:
    2001
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of endocrine disrupters on function of thyroid gland, adrenal glands and gonads
内分泌干​​扰物对甲状腺、肾上腺和性腺功能的影响
  • 批准号:
    11839003
  • 财政年份:
    1999
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Roles of Thyroid and Adrenal glands in the regulation of hypothalamo-hypophysial-ovarian axis in the rat.
甲状腺和肾上腺在大鼠下丘脑-垂体-卵巢轴调节中的作用。
  • 批准号:
    06660375
  • 财政年份:
    1994
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Roles of Thyroid and adrenal glands in the regulation of gonadotropins secretion during lactation in the rat
甲状腺和肾上腺在大鼠哺乳期促性腺激素分泌调节中的作用
  • 批准号:
    03660306
  • 财政年份:
    1991
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Mechanisms of suppression of gonadotropins secretion during lactation in the rat.
大鼠哺乳期间抑制促性腺激素分泌的机制。
  • 批准号:
    60560319
  • 财政年份:
    1985
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

相似海外基金

Identification of neural pathway for suckling stimulus using kisspeptin cell specific retrograde tracing
使用 Kisspeptin 细胞特异性逆行追踪识别哺乳刺激的神经通路
  • 批准号:
    15K21286
  • 财政年份:
    2015
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Investigation of kisspeptin-regulating mechanism by suckling stimulus
哺乳刺激对 Kisspeptin 调节机制的研究
  • 批准号:
    25870621
  • 财政年份:
    2013
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
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