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Roles of Thyroid and Adrenal glands in the regulation of hypothalamo-hypophysial-ovarian axis in the rat.

甲状腺和肾上腺在大鼠下丘脑-垂体-卵巢轴调节中的作用。

基本信息

批准号：
06660375
负责人：
TAYA Kazuyoshi
金额：
$ 1.34万
依托单位：
Tokyo University of Agriculture and Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06660375/
关键词：
Rat stress Thyroid gland Adrenal gland Ovary Prolactin ACTH Gonadotropin 性腺甲状腺刺激ホルモン放出ホルモン(TRH)

项目摘要

The functional relationship between thyroid, adrenal and gonadal hormones was investigated using adult male rats. Hypothyroidism was produced by the administration of 4-methy1-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouracil-treated rats as compared with euthyroid rats.Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH.The pituitary responsiveness to CRH for ACTH release markedly increased, whereas the adrenal responsiveness to ACTH for corticosterone release decreased. These results indicated that hypothyroidism causes adrenal dysfunction in adult male rats. Pituitary contents of LH and prolactin decreased in hypothyroid rats as compared with euthyroid rats. In addition, hypothyroidism lowered pituitary LH responsiveness to LHRH.Testicular responsiveness to human chorionic gonadotrophin for testosterone release, however, was not different between euthyroid and hypothyroid animals. These results indicated that hypothyroidism causes adrenal dysfunction and results in hypersecretion of ACTH from the pituitary gland. Adrenal dysfunction may contribute to the inhibition of LHRH secretion from the hypothalamus, possibly mediated by excess CRH.

用成年雄性大鼠研究了甲状腺、肾上腺和性腺激素之间的功能关系。4-甲基-2-硫氧尿嘧啶(硫氧尿嘧啶)经饮水灌胃2周后出现甲状腺功能减退。与正常大鼠相比，硫氧尿嘧啶治疗组大鼠血浆TSH浓度显著升高，三碘甲腺原氨酸和甲状腺激素浓度显著降低。甲减使大鼠血浆ACTH基础水平和垂体ACTH含量升高，垂体对CRH释放ACTH的反应性显著增强，而肾上腺对ACTH释放皮质酮的反应性降低。这些结果表明，甲状腺功能减退可导致成年雄性大鼠肾上腺功能障碍。与甲状腺功能正常大鼠相比，甲状腺功能低下大鼠脑垂体中的黄体生成素和催乳素含量降低。此外，甲状腺功能减退降低了垂体对LHRH的反应性，但睾丸对人绒毛膜促性腺激素释放睾酮的反应性在正常甲状腺和甲状腺功能减退动物之间没有差别。这些结果表明，甲状腺功能减退导致肾上腺功能障碍，并导致脑下垂体腺分泌ACTH。肾上腺功能障碍可能与下丘脑LHRH分泌抑制有关，其机制可能与CRH过多有关。