Development of nonshivering thermogenic capacity in the neonate.
新生儿不颤抖产热能力的发展。
基本信息
- 批准号:62570070
- 负责人:
- 金额:$ 1.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1987
- 资助国家:日本
- 起止时间:1987 至 1988
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In order to clarify the mechanism(s) of development of nonshivering thermogenesis (NST), the influence of noradrenaline (NA) and glucagon (G) on the ontogeny of NST in neonatal rats was investigated.The NA content of brown adipose tissue (BAT) was low at birth, and then increased repidly, whereas G content was already high before birth and maintained so after birth. Measurements of in vitro BAT oxygen consumption(tissue blocks in 4 % bovine serum albumin/ Krebs-Ringer phosphate buffer after 2 or 3 hr. preincubation; Clark-type oxygen electrode) showed that NA and G were capable of stimulating the tissue before birth, and the response increased markedly after birth. Around birth, the G response was same as the NA response. However, the G response became smaller by 5 days after birth, while the NA response remained in high until just before the weaning period. NA increased cAMP levels in BAT, and this effect became more marked in the later days of neonatal life. the G stimulation of BAT cAMP was smaller than the NA stimulation and showed no change over the experimental period. It was also suggested that NA as well as G increased IP_3 levels in BAT, and the responses became smaller in the later stages of neonatal life.These results suggest that G could play an important role in NST particulary in the very early period of neonatal life and that the G activation of thermogenesis may involve a different pathway from that of NA. Is was also shown that the present method for measuring oxygen consumption with BAT blocks was useful to evaluate the NST capacity of the BAT.
为了阐明非寒战性产热(NST)发生的机制,观察了去甲肾上腺素(NA)和胰高血糖素(G)对新生大鼠NST发生的影响。体外BAT耗氧量的测量(组织块在4%牛血清白蛋白/ Krebs-Ringer磷酸盐缓冲液中预孵育2或3小时后; Clark型氧电极)表明,NA和G能够刺激出生前的组织,出生后反应显著增加。出生前后,G反应与NA反应相同。然而,G反应在出生后5天变小,而NA反应一直保持在高水平,直到断奶期之前。NA增加BAT中的cAMP水平,并且这种效果在新生儿生命的后期变得更加显著。BAT cAMP的G刺激小于NA刺激,并且在实验期间没有显示出变化。NA和G均能使BAT中IP_3水平升高,且在新生儿后期反应减弱,提示G在新生儿早期NST中可能起重要作用,G激活产热可能涉及与NA不同的途径。本方法可用于评价BAT的NST能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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YAHATA Takehiro其他文献
YAHATA Takehiro的其他文献
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{{ truncateString('YAHATA Takehiro', 18)}}的其他基金
CLARIFICATION OF CONTROL MECHANISM OF NONSHIVERING THERMOGENESIS BY ANALYSIS OF GENE INFORMATION AND INTRACELLULAR SIGNAL TRANSDACTION SYSTEM
基因信息和细胞内信号传导系统分析阐明非颤抖生热的控制机制
- 批准号:
09670083 - 财政年份:1997
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on the inhibitory control system of nonshivering thermogenesis by gene signal analysis.
通过基因信号分析研究非颤抖产热的抑制控制系统。
- 批准号:
07670096 - 财政年份:1995
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Diverse intra-cellular control mechanisms of nonshivering thermogenesis. -The roles of glucagon and beta_3 agonist.
非颤抖产热的多种细胞内控制机制。
- 批准号:
03670072 - 财政年份:1991
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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CLARIFICATION OF CONTROL MECHANISM OF NONSHIVERING THERMOGENESIS BY ANALYSIS OF GENE INFORMATION AND INTRACELLULAR SIGNAL TRANSDACTION SYSTEM
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09670083 - 财政年份:1997
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on the inhibitory control system of nonshivering thermogenesis by gene signal analysis.
通过基因信号分析研究非颤抖产热的抑制控制系统。
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07670096 - 财政年份:1995
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Diverse intra-cellular control mechanisms of nonshivering thermogenesis. -The roles of glucagon and beta_3 agonist.
非颤抖产热的多种细胞内控制机制。
- 批准号:
03670072 - 财政年份:1991
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Regulation of Nonshivering Thermogenesis in Mammals
哺乳动物非颤抖产热的调节
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