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Relationship between body temperature and autonomic nervous tone in spontaneously hypertensive rat (SHR).

自发性高血压大鼠（SHR）体温与自主神经张力的关系。

基本信息

批准号：
62570075
负责人：
TSUCHIYA Katsuhiko
金额：
$ 1.15万
依托单位：
Institute of Tropical Medicine Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

Core temperature and autonomic nervous tones were compared spontneously hypertensive rate (SHR,200 mmHg), stroke-prone SHR(SHRSP,250 mmHg) and Kyoto-Wistar rats (WKY,120-130mmHg). 1) Body temperature; Each rat was placed in a small wire-mesch cage for the loose restraint, rectal temperature(Tre) and tail skin temperature (Ttail) were recorded continuously. Tre was estimated in 30 min of 60th to 90th min from the beginning of the restraint. Mean Tre in SHR,SHESP and WKY of 6-9 Months old were 38.7 0.3゜C,38.3 0.3 c and 37.7 0.1 C,respectively. Tre were in the oder SHR>SHRSP>WKY,though blood pressure were in the oder SHRSP>SHR-WKYW. 2) Threshold core temperature; during a gradual rising of air temperature at constant rate of 0.2゜C/min, stepwise increses in Ttail were observed which indicate the tail vasodilation. Threshold core temperature for the tail vasodilation in SHR,SHRSP and WKY were 38.9 0.1゜C,38.9 0.1゜C and 38.4 0.1゜C,respectively. Threshold core temperature in SHR was higher than those in other two strains and it in the SHRSP was lower than SHR. 3) Autonomic nervous tone ; Cardiac autonomic nervous tones were estimated by the pharmacological method (Lin and Horvath, 1972). In male rats of 6-7 months old, parasympathetic tones were 19.4%,15.9 % and 15.2%, sympathetic tones were 38.3%,24.0% and 29.6%, respectively. Both sympathetic and parasympathetic tones in SHR were highest among the three strains. 4) Effect of the restraint; Initial Tre in SHR,SHRSP and WKY (5-7M) were 38.4 0.1゜C,38.5 0.2゜C and 37.8 0.2 c,respectively. When the rat was placed in the restrain cage, Tre and heart rate incresed but ttail sudtainly decreased. At the biginning of the restraint, Tre gegan to increase and declined gradually toword the initial level. Maximal values of the Tre were observed between 10th to 30th min after beginning of the restraint. An upper shift of Tre by the restraint in SHR was larger than those in others, and these upper shift of Tre decreased with age.

比较心脏温度和自主神经张力自发性高血压率（SHR,200 mmHg）、卒中易发SHR（SHRSP,250 mmHg）和京都- wistar大鼠（WKY,120-130mmHg）。1)体温；将每只大鼠置于松散约束的小丝网笼中，连续记录直肠温度（Tre）和尾皮温度（tail）。据估计，在第60至90分钟的30分钟内，从限制开始。6-9月龄SHR、SHESP和WKY的平均Tre分别为38.7 0.3 C、38.3 0.3 C和37.7 0.1 C。3例为SHR>型shsp >型WKY，血压为SHRSP>型SHR- wkyw。2)临界堆芯温度；在空气温度以0.2℃/min的恒定速率逐渐升高期间，观察到尾部血管舒张逐渐增加。SHR、SHRSP和WKY中尾部血管舒张的阈值核心温度分别为38.9 0.1、38.9 0.1和38.4 0.1摄氏度。SHR菌株的临界核心温度高于其他两种菌株，而SHRSP菌株的临界核心温度低于SHR菌株。3)自主神经张力；通过药理学方法估计心脏自主神经张力（Lin和Horvath， 1972）。6 ~ 7月龄雄性大鼠副交感神经张力分别为19.4%、15.9%和15.2%，交感神经张力分别为38.3%、24.0%和29.6%。SHR的交感神经和副交感神经张力均最高。4)约束效果；SHR、SHRSP和WKY （5-7M）的初始Tre分别为38.4 0.1、38.5 0.2和37.8 0.2 C。当将大鼠置于约束笼中时，大鼠的心率和心率增加，但尾巴突然减少。在约束开始时，Tre开始上升，并逐渐向初始水平下降。在约束开始后的第10至30分钟观察到trei的最大值。在SHR抑制下，tre3的上移幅度较大，且随年龄的增长而减小。