Contribution of Sympathetic Nerve Activity to the Thoracic Duct Lymph Flow during Acute Heat Stress

急性热应激期间交感神经活动对胸导管淋巴流量的贡献

• 批准号: 62570077
• 负责人: YAMADA Seiji
• 金额: $ 0.32万
• 依托单位: University of Occupational and Environmental Health(UOEH)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570077/
• 关键词: Acute heat stress; Thoracic duct lymph; Temperature dependence; Pulse-Doppler flowmeter; Regional blood flow; Redistribution of the blood flow; Regional lymph flow; ラット; 胸管リンパ流; 骨格筋運動; 自律神経活動; パルスドップラー血流計

Effects the acute stress on the regional lymph into the thoracic duct in conscious rats were examined. We found the temperature dependence of the regional lymph into the thoracic duct during heat stress, i.e., the decrease of the regional lymph flow into the thoracic duct followed the increase of the colonic temperatrure. The regional lymph flow into the thoracic duct decrease by 18%, 30% and 40% according to the increase of the colonic temperature in 1゜C, 2゜C and 3゜C, respectively. These findings suggest that the regional lymph flow into the thoracic duct was dependent on the colonic temperature during acute heat stress.To evaluate the causes of the decrease of the lymph flow into the thoracic duct, we measured visceral(renal or mesenteric) blood flow and the hindlimb(the abdominal aorta on the distal side of the renal artery) blood flow as non-viscreal(skin ＆ muscle) blood flow by a pulse Doppler flowmeter. Body temperature was raised by 2゜C with putting the rats into the oven controlled ambient temperature. Regional blood flow of the hindlimb decreased in 33%. The mesenteric or renal blood flow decreased in 34% or 19%, respectively. We calculated the changes of the regional lymph from the visceral and non-visceral organs into the thoracic duct, assuming that the changes of the regional blood flow directly affect the changes of the formation of the regional lymph. The calculated decrease of the lymph flow into the thoracic duct in 21%, which was 70% of the measured decrease of the lymph flow into the thoracic duct(30%). These results suggest that the changes of the regional blood flow during acute heat stress exert the predominant influence on the rate of the regional lymph flow into the thoracic duct in the rat.

观察急性应激对清醒大鼠胸导管区域淋巴的影响。我们发现热应激时进入胸导管的区域淋巴对温度的依赖性，即进入胸导管的区域淋巴流量随着结肠温度的升高而减少。结肠温度升高1、2、3℃时，进入胸导管的区域淋巴流量分别减少18%、30%和40%。这些结果表明，在急性热应激期间，进入胸导管的区域淋巴流量依赖于结肠温度。为了评估进入胸导管的淋巴流量减少的原因，我们用脉冲多普勒流量计测量了内脏（肾脏或肠系膜）血流和后肢（肾动脉远端的腹主动脉）血流作为非内脏（皮肤和肌肉）血流。将大鼠置于烤箱控制的环境温度中，体温升高2 C。后肢局部血流量减少33%。肠系膜血流量和肾血流量分别减少34%和19%。我们计算了从内脏器官和非内脏器官进入胸导管的区域淋巴的变化，假设区域血流量的变化直接影响区域淋巴形成的变化。计算得出进入胸导管的淋巴流量减少了21%，是测量到的进入胸导管的淋巴流量减少量（30%）的70%。这些结果表明，急性热应激时区域血流量的变化对大鼠胸导管区域淋巴流量的速率起主要影响作用。

项目成果

Seiji YAMADA: "Responses of lymph and protein flow from hindlimb into the thoracic duct by passive limb movement in rats and rabbits." in preparation.

Seiji YAMADA：“通过大鼠和兔子的被动肢体运动，淋巴和蛋白质从后肢流入胸导管的反应。”

Seiji YAMADA: "Contribution of the regional blood flow changes to the regional lymph flow into the thoracic duct in rats during acute heat stress." in preparation.

Seiji YAMADA：“急性热应激期间，大鼠局部血流变化对流入胸导管的局部淋巴液的影响。”

山田 誠二: 日本生気象学会雑誌. 24. 49 (1987)

Seiji Yamada：日本生物气象学会杂志，24. 49 (1987)。

Seiji YAMADA: "Temperature dependence of the thoracic duct lymph flow in the rat during acute heat stress." in preparation.

Seiji YAMADA：“急性热应激期间大鼠胸导管淋巴流的温度依赖性。”

Seiji YAMADA: J. Physiol Soc. Japan. 49. 564 (1987)

山田诚二：J. Physiol Soc。