Modifying effects of carotenoids on the host-defense mechanism

类胡萝卜素对宿主防御机制的改变作用

• 批准号: 62570257
• 负责人: TOMITA Yoshifumi
• 金额: $ 0.32万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570257/
• 关键词: carotenoids; tumor immunity; 生体防御機能; カロチン; カロチノイド; 生体防御

Epidemiological studies have revealed the involvement of environmental factors, especially nutritional and dietary factors, in incidence of some sites of cancer and of some infectious diseases. The reverse correlation between intake of green-yellow vegetables and the risk of cancer has been reported increasingly and supported by some experimental studies suggesting one of possible means to prevent the diseases. However, the precise mechanism for the preventive effect of green-yelow vegetables is not clarified. This study deals with the effects of carotenoids, abundant in green-yellow vegetables, on the host-defense mechanism.Administration of carotenoids significantly enhanced the immunological rejection against syngeneic tumors. The enhancing effect is apparently not related to their provitamin a potency, but related to their molecular structures. This finding seems to suggest that carotenoids in green-yelow vegetables may contribute to the prevention of cancer or infectious diseases by augmenting the host-defense mechanism. Metabolic conversion from carotenoids to retinol-like form may be essential to the exhibition of the effect, because retinol form of vitamin A enhanced the tumor rejection as shown in our previous work, however, present study was not intended to obtain any information on their metabolism. Further works in under way for elucidation of the mechanism.

流行病学研究表明，环境因素，特别是营养和饮食因素，参与了某些部位癌症和某些传染病的发生。绿黄色蔬菜的摄入量与癌症风险之间的负相关关系越来越多地被报道，并得到了一些实验研究的支持，这些研究表明，这是预防这种疾病的可能方法之一。然而，绿黄素预防效果的确切机制尚不清楚。本研究探讨了绿黄色蔬菜中丰富的类胡萝卜素对宿主防御机制的影响。类胡萝卜素的应用显著增强了对同种肿瘤的免疫排斥。这种增强作用显然与它们的维生素a原效力无关，而与它们的分子结构有关。这一发现似乎表明，绿黄色蔬菜中的类胡萝卜素可能通过增强宿主防御机制而有助于预防癌症或传染病。从类胡萝卜素到类视黄醇的代谢转换可能是发挥作用的关键，因为视黄醇形式的维生素A如我们以前的工作所显示的那样，增强了肿瘤的排斥反应，然而，本研究并不打算获得关于它们的代谢的任何信息。进一步的工作正在进行中，以阐明这一机制。

项目成果

富田純史: J.Natl.Cancer Inst.78. 679-681 (1982)

富田淳二：J.Natl.Cancer Inst.78（1982）。

Tomita, Yoshifumi: "Augmentation of tumor immunity against syngeneic tumors in mice by beta-carotene." J. Natl. Cancer Inst.78. 679-681 (1982)

Tomita，Yoshifumi：“通过 β-胡萝卜素增强小鼠对同基因肿瘤的肿瘤免疫力。”